Funding Amount

Varies

Deadline

Rolling / Open

Grant Type

foundation

Overview

Cure Quest

Program Overview: Sophia's Fund is committed to supporting research that specifically works toward a cure for childhood cancers and brain tumors. The program funds clinical research initiatives designed to improve treatments and increase survival rates.

    Rationale

  • Childhood cancer is the leading cause of death by disease in children
  • Childhood cancer treatments remain grossly underfunded
  • Program aims to support more successful and less harmful treatments

    Research Focus

  • Rare childhood cancers
  • Brain tumors (DIPG - diffuse intrinsic pontine glioma)
  • Neuroblastoma (relapsed, refractory, or progressive)
  • Innovative combination treatments and personalized immunotherapy
  • Molecular-guided therapy
  • Cancer vaccine development
  • Adoptive T cell therapy

Recent Research Funded

PEACH Protocol - $7,500 contributed

  • Prospective treatment for diffuse intrinsic pontine glioma (DIPG) and recurrent neuroblastoma

  • Human clinical trial led by pediatric oncology teams at University of Florida and Atrium Health Levine Children's in Charlotte, N.C.

  • Tests innovative combination of molecular-guided therapy and personalized immunotherapy

  • Uses unique genetic information to design three-pronged approach: tailored drug treatment, cancer vaccine with dendritic cells, and adoptive T cell therapy
  • DFCI Relapsed, Refractory or Progressive Neuroblastoma - $1,500 contributed

  • Dana Farber Cancer Institute & Jimmy Fund

  • Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or without Eflornithine (DFMO)

  • IND# 141913

  • Research on children with relapsed, refractory or progressive neuroblastoma
  • Focus Areas & Funding Uses

    Fields of Work

    cancerscience-research

    Categories

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