BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

Q: When is the deadline for BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)?

The deadline is October 6, 2028.

National Institutes of Health

Federal Grants for Science Research

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Funding Amount

$10,000,000 total

Deadline

October 6, 2028

912 days left

Grant Type

federal

Overview

BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

This notice of funding opportunity (NOFO) supports efforts to disseminate resources for integration into neuroscience research practice. The resource(s) should be relevant to the goals of the BRAIN Initiative as outlined in the "BRAIN 2025: A Scientific Vision" and "The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures" and shared broadly to the neuroscience community. The resource(s) should address compelling needs of neuroscience researchers that are otherwise unavailable or impractical in their current form. Activities must include dissemination of an existing resource, and may include one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and/or specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: RFA-NS-27-001
Total Funding: $10,000,000
Expected Awards: 20
Instrument: cooperative_agreement

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations re

Eligibility

Eligible Applicant Types

federally_recognized_native_american_tribal_governmentsstate_governmentscounty_governmentsindependent_school_districtssmall_businessesnonprofits_non_higher_education_with_501c3for_profit_organizations_other_than_small_businessesprivate_institutions_of_higher_educationnonprofits_non_higher_education_without_501c3city_or_township_governmentsother_native_american_tribal_organizationspublic_and_state_institutions_of_higher_educationotherspecial_district_governmentspublic_and_indian_housing_authorities

How to Apply

RFA-NS-27-001-Full-Announcement.html

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<title>RFA-NS-27-001: BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

<div>

<div data-element-id="261373" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261373' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
</div>

<div class="row" data-index="2">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261374" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261374' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
</div>
<div class=" col-md-8 datacolumn">
<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
</div>
</div>

<div class="row" data-index="4">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261376" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261376' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
</div>
<div class=" col-md-8 datacolumn">
<p>National Institute of Neurological Disorders and
Stroke (<a href="https://www.ninds.nih.gov/" target="_blank" rel="noreferrer">NINDS</a>)
<p>National Eye Institute (<a href="https://www.nei.nih.gov/" target="_blank" rel="noreferrer">NEI</a>)
</p>
<p>National Institute on
Aging (<a href="https://www.nia.nih.gov/" target="_blank" rel="noreferrer">NIA</a>)
</p>
<p>National Institute on Alcohol Abuse and Alcoholism (<a href="https://www.niaaa.nih.gov/" target="_blank" rel="noreferrer">NIAAA</a>)
</p>
<p>National Institute of Biomedical Imaging and Bioengineering (<a href="https://www.nibib.nih.gov/" target="_blank" rel="noreferrer">NIBIB</a>)
</p>
<p>Eunice Kennedy Shriver National Institute of Child Health and Human Development (<a href="https://www.nichd.nih.gov/" target="_blank" rel="noreferrer">NICHD</a>)
</p>
<p>National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/" target="_blank" rel="noreferrer">NIDCD</a>)
</p>
<p>National Institute on Drug Abuse (<a href="https://www.drugabuse.gov/" target="_blank" rel="noreferrer">NIDA</a>)
</p>
<p>National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml" target="_blank" rel="noreferrer">NIMH</a>)
</p>
<p>National Center for Complementary and Integrative Health (<a href="https://nccih.nih.gov/" target="_blank" rel="noreferrer">NCCIH</a>)
</p>

<p>All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
</p>
<p>Office of Behavioral and Social Sciences Research (<a href="https://obssr.od.nih.gov/" target="_blank" rel="noreferrer">OBSSR</a>)
</p>
</div>
</div>

<div class="row" data-index="6">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261378" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261378' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
</div>
<div class=" col-md-8 datacolumn">
<span class="title">BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)</span>
</div>
</div>

<div class="row" data-index="7">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261379" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261379' tabindex='-1' aria-hidden='true'></a>Activity Code
</div>
<div class=" col-md-8 datacolumn">
<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=u24&Search.x=0&Search.y=0&sort=ac&Search_Type=Activity&text_prev=">U24</a> Resource-Related Research Projects – Cooperative Agreements</p>
</div>
</div>

<div class="row" data-index="8">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261380" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261380' tabindex='-1' aria-hidden='true'></a>Announcement Type
</div>
<div class=" col-md-8 datacolumn">
Reissue of

RFA-NS-23-026

<br/>
</div>
</div>

<div class="row" data-index="9">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261381" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261381' tabindex='-1' aria-hidden='true'></a>Related Notices
</div>
<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
</div>
</div>

<div class="row" data-index="10">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261382" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261382' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
</div>
<div class=" col-md-8 datacolumn">
<span class="noticenum">RFA-NS-27-001</span>
</div>
</div>

<div class="row" data-index="11">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261383" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261383' tabindex='-1' aria-hidden='true'></a>Companion Funding Opportunity
</div>
<div class=" col-md-8 datacolumn">
None
</div>
</div>

<div class="row" data-index="12">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261384" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261384' tabindex='-1' aria-hidden='true'></a>Number of Applications
</div>
<div class=" col-md-8 datacolumn">
<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.</p>
</div>
</div>

<div class="row" data-index="13">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261385" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261385' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
</div>
<div class=" col-md-8 datacolumn">
93.372, 93.853, 93.173, 93.279, 93.286, 93.866, 93.273, 93.213, 93.242, 93.865, 93.867
</div>
</div>

<div class="row" data-index="14">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261386" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261386' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Purpose
</div>
<div class=" col-md-8 datacolumn">
<p>This notice of funding opportunity (NOFO) supports efforts to disseminate resources for integration into neuroscience research practice. The resource(s) should be relevant to the goals of the BRAIN Initiative as outlined in the "<a href="http://braininitiative.nih.gov/pdf/BRAIN2025_508C.pdf">BRAIN 2025: A Scientific Vision</a>" and "<a href="https://braininitiative.nih.gov/sites/default/files/images/brain_2.0_6-6-19-final_revised10302019_508c.pdf">The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures</a>" and shared broadly to the neuroscience community. The resource(s) should address compelling needs of neuroscience researchers that are otherwise unavailable or impractical in their current form. Activities must include dissemination of an existing resource, and may include one or more of the following activities: distribution of tools and reagents; user training on the usage of new technologies or techniques; providing access to existing technology platforms and/or specialized facilities; minor improvements to increase the scale/efficiency of resource production and delivery; minor adaptations to meet the needs of a user community.</p>
</div>
</div>

<div class="row" data-index="16">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261388" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261388' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
</div>
<div class=" col-md-8 datacolumn">
<p style="margin-left:.25in;">To provide extramural research support for the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiatives aim of revolutionizing our understanding of the brain and its function in unprecedented detail. The NIH BRAIN Initiatives focus is foundational development of new technologies and tools to map, monitor, and modulate brain circuits in model systems and humans – toward the ultimate goal of treating and curing human brain disorders. BRAIN Initiative research adheres to open, and ethical science – and requires diverse expertise across all technical domains.</p>
</div>
</div>

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<a id='_bookmark261389' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261390" data-element-required="false" data-element-has-value="true" data-section-code="KD" data-element-type="DATE">
<a id='_bookmark261390' tabindex='-1' aria-hidden='true'></a>Posted Date
</div>
<div class=" col-md-8 datacolumn">
February 09, 2026
</div>
</div>

<div class="row" data-index="19">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261391" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261391' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
</div>
<div class=" col-md-8 datacolumn">
May 10, 2026
</div>
</div>

<div data-element-id="261393" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261393' tabindex='-1' aria-hidden='true'></a>
<table class="table table-bordered table-striped table-hover eraDataTable" id="keyDatesContentTable">
<thead>
<tr>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
</tr>
<tr>
<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">Earliest Start Date</th>
</tr>
</thead>
<tbody>
<tr>
<td>
June 10, 2026
</td>
<td>
June 10, 2026
</td>
<td>
Not Applicable
</td>
<td>November 2026</td>
<td> January 2027

</td>
<td>April 2027</td>
</tr>
<tr>
<td>
October 06, 2026
</td>
<td>
October 06, 2026
</td>
<td>
Not Applicable
</td>
<td>March 2027</td>
<td> May 2027

</td>
<td>July 2027</td>
</tr>
<tr>
<td>
June 10, 2027
</td>
<td>
June 10, 2027
</td>
<td>
Not Applicable
</td>
<td>November 2027</td>
<td> January 2028

</td>
<td>April 2028</td>
</tr>
<tr>
<td>
February 18, 2028
</td>
<td>
February 18, 2028
</td>
<td>
Not Applicable
</td>
<td>July 2028</td>
<td> October 2028

</td>
<td>December 2028</td>
</tr>
<tr>
<td>
October 06, 2028
</td>
<td>
October 06, 2028
</td>
<td>
Not Applicable
</td>
<td>March 2029</td>
<td> May 2029

</td>
<td>July 2029</td>
</tr>
</tbody>
</table>
</div>

<div data-element-id="261395" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261395' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="261401" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261401' tabindex='-1' aria-hidden='true'></a>Expiration Date
</div>
<div class=" col-md-8 datacolumn">
October 07, 2028
</div>
</div>

<div class="row" data-index="29">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261402" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261402' tabindex='-1' aria-hidden='true'></a>Due Dates for E.O. 12372
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="heading4" tabindex="0" data-element-id="262221" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark262221' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
</div>

<div data-element-id="262221" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<p>It is critical that applicants follow the instructions in the Research (R) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>).</p><p>Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions.</p><p><strong>Applications that do not comply with these instructions may be delayed or not accepted for review.</strong></p>
</div>

<div data-element-id="261403" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261403' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li><li>Use <a href="https://grants.gov/search-grants?oppStatuses=closed|archived|posted|forecasted&fon=PA-25-301">Grants.gov</a> Workspace to prepare and submit your application and <a href="http://public.era.nih.gov/commons/">eRA Commons</a> to track your application.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

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<a id='_bookmark261405' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
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<a id='_bookmark261406' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
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<a id='_bookmark261407' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;"><strong>Background</strong></p><p style="margin-left:0in;">Since 2014, the <a href="https://braininitiative.nih.gov/">Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative</a> has aimed to accelerate the development and application of innovative neurotechnologies, enabling researchers to produce a new dynamic picture of the brain that reveals how individual cells and complex neural circuits interact in both time and space. It is expected that these advances will ultimately lead to new ways to treat and prevent brain disorders.</p><p style="margin-left:0in;">As one of several federal agencies involved in the BRAIN Initiative, NIH's contributions to the BRAIN Initiative were initially guided by "<a href="https://braininitiative.nih.gov/vision/nih-brain-initiative-reports/brain-2025-scientific-vision">BRAIN 2025: A Scientific Vision</a>," a strategic plan that detailed seven <a href="https://braininitiative.nih.gov/strategic-planning/brain-priority-areas">high-priority research areas</a>. This plan was updated and enhanced in 2019 by: "<a href="https://braininitiative.nih.gov/sites/default/files/images/brain_2.0_6-6-19-final_revised10302019_508c.pdf">The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures</a>" and "<a href="https://braininitiative.nih.gov/sites/default/files/images/bns_roadmap_11_october_2019_sent_to_acd_for_oct_2019_revised_10282019_508c.pdf">The BRAIN Initiative and Neuroethics: Enabling and Enhancing Neuroscience Advances for Society</a>." This and other BRAIN Initiative Notices of Funding Opportunities (NOFOs) are based on this vision and issued with input from Advisory Councils of the <a href="https://braininitiative.nih.gov/about/brain-partners">10 NIH Institutes and Centers supporting the BRAIN Initiative</a>, as assisted by the <a href="https://braininitiative.nih.gov/about/multi-council-working-group">NIH BRAIN Multi-Council Working Group</a> and <a href="https://braininitiative.nih.gov/about/neuroethics-working-group">Neuroethics Working Group</a>.</p><p style="margin-left:0in;">The NIH BRAIN Initiative recognizes innovative ideas require creativity, scientific expertise, and experience. There are many benefits that flow from a scientific workforce with team participation including: fostering scientific innovation, enhancing global competitiveness, contributing to robust learning environments, improving the quality of the research, and enhancing public trust</p><p style="margin-left:0in;">The NIH also encourages businesses to participate in the BRAIN Initiative. It is possible for companies to submit applications directly to BRAIN Initiative program announcements or to collaborate with academic researchers in joint submissions. Small businesses should consider applying to one of the  <a href="http://braininitiative.nih.gov/funding/index.htm">BRAIN Initiative small business NOFOs</a></p><p style="margin-left:0in;">The BRAIN Initiative requires a high level of coordination and sharing between investigators. It is expected that BRAIN Initiative recipients will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings and in other activities such as the BRAIN Initiative Conference. The data sharing expectations for BRAIN Initiative awards can be found at <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-MH-19-010.html">NOT-MH-19-010</a>.</p><p style="margin-left:0in;">This NOFO is related to the recommendations in the <a href="https://braininitiative.nih.gov/vision/nih-brain-initiative-reports/brain-2025-scientific-vision">BRAIN 2025</a> (Section III, Part 8b) and the <a href="https://braininitiative.nih.gov/vision/nih-brain-initiative-reports/brain-20-report-cells-circuits-toward-cures">BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures</a> (Priority Area 8, Section III) Reports. Specifically, this NOFO solicits applications that will address the recommendations on "Dissemination and training in new technologies" As noted in the BRAIN 2.0 report new tools and new knowledge should be shared broadly to maximize the value of the BRAIN Initiative and to seed new paths of inquiry.</p><h4>Objectives</h4><p>The overall goal of this NOFO is to accelerate the scientific impact of the BRAIN Initiative through rapid dissemination of developed and validated technologies and resources broadly to the neuroscience research community. Awards from this RFA will be made for no more than 5 years, with a possibility of one renewal.</p><p>Projects may accomplish this goal by engaging in one or more of the following types of activities:</p><ul><li>Production and distribution of reagents (e.g., antibodies, chemical probes, transgenic lines) using quality control manufacturing processes</li><li>Services providing customized instrumentation based on end user needs</li><li>Provision of state-of-art components, devices, or integrated systems (e.g., for assaying neural activity and/or connectivity) either distributed to end users or operated as specialized core facilities with user engagement</li><li>Resources focused on enabling the translation of neurotechnologies for human use</li><li>Maintenance, minor enhancements, and distribution of open-source computational models and software packages</li><li>User facilities that enable scientists from outside institutions to utilize specialized tools or techniques</li><li>Training in usage of the resource</li></ul><p>The following are examples of projects responsive to this NOFO. These are representative, but not exhaustive, examples.</p><ul><li>Consortium that provides screening services for voltage sensors and other probes for identifying changes in membrane potential or network modulatory states</li><li>Resource that provides reliable multichannel microelectrodes to the neuroscience community that are compatible with other recording technologies, such as optical imaging and stimulation or MRI</li><li>Imaging services for large-scale recording of neural activity from multiple brain areas or for large-scale sampling/manipulation of cellular activity with simultaneous whole-brain activity measurements</li><li>Dissemination of novel miniaturized wireless imaging systems and serving as a core resource for researchers</li><li>A resource that gathers, standardizes and streamlines the distribution of transgenic mouse models for neuroscience research</li></ul><p>This NOFO will support applications which address one or more of the specific goals of the BRAIN Initiative, as described in the planning document "<a href="http://braininitiative.nih.gov/pdf/BRAIN2025_508C.pdf">BRAIN 2025: A Scientific Vision</a>" and updated and enhanced in 2019 by "<a href="https://braininitiative.nih.gov/sites/default/files/images/brain_2.0_6-6-19-final_revised10302019_508c.pdf">The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures</a>". Applications are not limited to existing BRAIN Initiative investigators or to technologies previously developed using BRAIN Initiative or NIH funds, nor must the end user community be limited to investigators with BRAIN Initiative funding. End users may include those studying disease relevant mechanisms. Projects should address compelling needs of broad communities of investigators or should justify the impact and unmet opportunity of providing the services at smaller scales.</p><p>Proposed techniques, resources or approaches must be at a stage wherein the potential value for research is well established, through publications or other demonstration methods, and dissemination must occur by early in year 2. Projects focused on developing novel and unproven technologies are not responsive to this NOFO. Applicants developing new technologies are encouraged to submit to one of the <a href="https://braininitiative.nih.gov/funding/funding-opportunities">BRAIN technology development NOFOs</a>. Applications to develop web-accessible data archives are strongly recommended to consider funding through <a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-110.html">RFA-MH-25-110</a>, BRAIN Initiative: Data Archives for the BRAIN Initiative. Please see <a href="https://www.braininitiative.nih.gov/funding/">https://www.braininitiative.nih.gov/funding/</a> for more details about these and other BRAIN Initiative programs.</p><p>Integration of proven techniques to produce new experimental systems, or application of existing technologies to produce new reagents such as genetic lines or constructs with an existing technology, are appropriate, but need to be described clearly with timelines for completion of development and testing. Clear value to the intended user group must be demonstrated in the application and dissemination must be planned by early year 2.</p><p>For projects proposing the development of novel technologies/resources with commercial potential, potential applicants should consider funding through the Small Business Innovation Research (SBIR) program or the Small Business Technology Transfer (STTR) program. Please see: <a href="https://sbir.nih.gov/">seed..nih.gov/</a> for more details about these technology development programs.</p><p>Resources are expected to be free from any patent or licensing constraints that would unduly restrict academic research use and impede achieving the goals of this funding program. For resources requiring material from human subjects (e.g. DNA, fibroblasts, blood, tissue), broad sharing of the resource and any derivatives with academic and industry investigators is expected, consistent with achieving the goals of this program and consistent with applicable laws, regulations, and informed consents. In cases where the disseminated resource involves patented materials across several institutions, it is expected that these institutions utilize standard or model agreements in order to reduce negotiation cost and time.</p><p>Applicants are strongly encouraged to consult the Scientific/Research Contact listed below to discuss the alignment of their proposed work with the goals of this NOFO, and the BRAIN Initiative Program.</p><h4> </h4><h4><strong>Milestones</strong></h4><p>The success of the project will be facilitated by the adoption of clear, quantitative milestones with realistic and efficient timelines. Applications must include proposed milestones for each year of requested support, which will be evaluated as part of the review process. The milestones and timeline should include the timing and quantity of dissemination of the resource to the neuroscience community. <strong>Applications that fail to include annual milestones will be considered incomplete and will be withdrawn before review.</strong> Final version of milestones will be agreed upon at the time of award. If justified, future year milestones may be revised based on data and information obtained in the current year.</p><h4> </h4><h4> </h4><h4><strong>Applications Not Responsive to this NOFO:</strong></h4><p><strong>Proposed research that is not responsive to this NOFO and will not be reviewed include the following:</strong></p><ul><li>Projects focused on developing novel and unproven technologies</li><li>Projects which lack clear indication that the resource is well established and validated, through publications or other demonstration methods.</li><li>Projects where dissemination is not planned to occur by early year 2.</li><li>Projects that support clinical trials or provide patient services. Applicants considering such efforts are encouraged to explore alternative funding mechanisms.</li><li>Projects proposing repositories of brain and related bio-specimens. </li></ul>
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<a id='_bookmark261410' tabindex='-1' aria-hidden='true'></a><p>See <a href="#_Section_VIII._Other">Section VIII. Other Information</a> for award authorities and regulations.</p>
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<a id='_bookmark261411' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
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<a id='_bookmark261412' tabindex='-1' aria-hidden='true'></a>Funding Instrument
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<div class=" col-md-8 datacolumn">
<p>Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.</p>
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<a id='_bookmark261413' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
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<div class=" col-md-8 datacolumn">
New
<br>
Renewal
<br>
Resubmission
<br>
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<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261415' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116">OER Glossary</a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provide details on these application types. Only those application types listed here are allowed for this NOFO.</p>
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<a id='_bookmark261416' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
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<p>Not Allowed: Only accepting applications that do not propose clinical trials.</p>
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<a id='_bookmark261417' tabindex='-1' aria-hidden='true'></a><p><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a></p>
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<a id='_bookmark261418' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
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<p style="margin-left:0in;">The NIH anticipates providing $10M per year to fund an estimated 10 to 20 awards.</p>
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<a id='_bookmark261419' tabindex='-1' aria-hidden='true'></a>Award Budget
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<p>Application budgets are not limited but need to reflect the actual needs of the proposed project.</p>
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<a id='_bookmark261420' tabindex='-1' aria-hidden='true'></a>Award Project Period
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<p style="margin-left:0in;">Support may be requested for up to 5 years.</p>
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<a id='_bookmark261421' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
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<a id='_bookmark261422' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
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<a id='_bookmark261423' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
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<a id='_bookmark261424' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
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<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized)</li></ul>
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<a id='_bookmark261425' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>

<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
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<a id='_bookmark261426' tabindex='-1' aria-hidden='true'></a><p>Other</p>

<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
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<a id='_bookmark261427' tabindex='-1' aria-hidden='true'></a><p><strong>Applications Involving the NIH Intramural Research Program</strong></p><p>The requests by NIH intramural scientists will be limited to the incremental costs required for participation.   As such, these requests will not include any salary and related fringe benefits for career, career conditional or other Federal employees (civilian or uniformed service) with permanent appointments under existing position ceilings or any costs related to administrative or facilities support (equivalent to Facilities and Administrative or F&A costs).  These costs may include salary for staff to be specifically hired under a temporary appointment for the project, consultant costs, equipment, supplies, travel, and other items typically listed under Other Expenses.  Applicants should indicate the number of person-months devoted to the project, even if no funds are requested for salary and fringe benefits.</p><p>If selected, appropriate funding will be provided by the NIH Intramural Program. Intellectual property will be managed in accord with established policy of NIH in compliance with Executive Order 10096, as amended, 45 CFR Part 7; patent rights for inventions developed in NIH facilities are NIH property unless NIH waives its rights.</p><p>Should an extramural application include the collaboration with an intramural scientist, no funds for the support of the intramural scientist may be requested in the application.  The intramural scientist may submit a separate request for intramural funding as described above. Intramural scientist cannot be a multi-PI on an extramural award.</p>
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<a id='_bookmark261428' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/Foreign Collaborations</h4>
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<a id='_bookmark261429' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organizations) <strong>are not</strong> eligible to apply.</p>
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<a id='_bookmark261430' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
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<a id='_bookmark261431' tabindex='-1' aria-hidden='true'></a><p>Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the <em>NIH Grants Policy Statement</em></a>, <strong>are </strong>allowed. </p>
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<a id='_bookmark262151' tabindex='-1' aria-hidden='true'></a><p>NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.</p><p>Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or <a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_1/1.2_definition_of_terms.htm">foreign components</a>, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.</p>
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Deadline

April 13, 2026

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BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

Overview

BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

Details

Eligibility

Eligibility

Eligible Applicant Types

How to Apply

RFA-NS-27-001-Full-Announcement.html

Focus Areas & Funding Uses

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