Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
National Institutes of Health
Funding Amount
$1,300,000 total
Deadline
January 9, 2029
1007 days left
Grant Type
federal
Overview
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
This Notice of Funding Opportunity (NOFO) encourages grant applications for Animal and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research. Proposed Animal and Biological Material Resource Centers must have broad application to multiple NIH Institutes or Centers (ICs) to align with the ORIP"s NIH-wide mission (https://orip.nih.gov/about-orip). This funding opportunity is designed to support both continuation of existing resources and to develop new ones when appropriate. Of special interest of the announcement is a requirement of the Center"s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application, and ORIP's program priorities.
Details
- Agency: National Institutes of Health
- Department: Department of Health and Human Services
- Opportunity #: RFA-OD-25-011
- Total Funding: $1,300,000
- Expected Awards: 2
- Instrument: grant
Eligibility
Refer to Section III. Eligibility Information for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Eligibility
Eligible Applicant Types
How to Apply
RFA-OD-25-011-Full-Announcement.html
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<title>RFA-OD-25-011: Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)</title>
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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>
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<a id='_bookmark259587' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark259588' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark259590' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<div class=" col-md-8 datacolumn">
<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (<a href="https://orip.nih.gov/" target="_blank" rel="noreferrer">ORIP</a>)
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<a id='_bookmark259592' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)</span>
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<a id='_bookmark259593' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=p40&Search.x=0&Search.y=0&Search_Type=Activity">P40</a> Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants</p>
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<a id='_bookmark259594' tabindex='-1' aria-hidden='true'></a>Announcement Type
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Reissue of
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-OD-23-001.html" target="_blank" rel="noreferrer">RFA-OD-23-001</a>
<br/>
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<a id='_bookmark259595' tabindex='-1' aria-hidden='true'></a>Related Notices
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<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark259596' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">RFA-OD-25-011</span>
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<a id='_bookmark259597' tabindex='-1' aria-hidden='true'></a>Companion Notice of Funding Opportunity
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None
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<a id='_bookmark259598' tabindex='-1' aria-hidden='true'></a>Number of Applications
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<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.</p>
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<a id='_bookmark259599' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
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<div class=" col-md-8 datacolumn">
93.351
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<a id='_bookmark259600' tabindex='-1' aria-hidden='true'></a>Notice of Funding Opportunity Purpose
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<p>This Notice of Funding Opportunity (NOFO) encourages grant applications for Animal and Biological Material Resource Centers. These Centers provide support for special colonies of laboratory animals and associated services, as well as other resources such as informatics tools, reagents, cultures (cells, tissues, and organs) and genetic stocks that serve the biomedical research community in a variety of research areas on a local, regional, and national basis. The goal of projects supported by this NOFO is to provide research resources that facilitate optimization and enhancement of scientific rigor, transparency, and experimental reproducibility of biomedical research. Proposed Animal and Biological Material Resource Centers must have broad application to multiple NIH Institutes or Centers (ICs) to align with the ORIP’s NIH-wide mission (<a href="https://ThisNoticeofFundingOpportunity(NOFO)encouragesgrantapplicationsforAnimalandBiologicalMaterialResourceCenters.TheseCentersprovidesupportforspecialcoloniesoflaboratoryanimalsandassociatedservices,aswellasotherresourcessuchasinformaticstools,reagents,cultures(cells,tissues,andorgans)andgeneticstocksthatservethebiomedicalresearchcommunityinavarietyofresearchareasonalocal,regional,andnationalbasis.ThegoalofprojectssupportedbythisNOFOistoprovideresearchresourcesthatfacilitateoptimizationandenhancementofscientificrigor,transparency,andexperimentalreproducibilityofbiomedicalresearch.ProposedAnimalandBiologicalMaterialResourceCentersmusthavebroadapplicationtomultipleNIHInstitutesorCenters(ICs)toalignwiththeORIP’sNIH-widemission(https://orip.nih.gov/about-orip).Thisfundingopportunityisdesignedtosupportbothcontinuationofexistingresourcesandtodevelopnewoneswhenappropriate.OfspecialinterestoftheannouncementisarequirementoftheCenter’sclosecoordinationwitheffortstodevelopnewapproachmethodologies(NAMS)thatcomplementtraditionalanimal-basedresearch.Theseincludecellculture,organoids,computationalmodels,andmicrophysiologicalsystems.AppliedResearchComponentshouldincludestudiestogeneratecomparativedatatoincreaseapplicabilityofNAMsandpromoteintegrationofthemostpredictivehumandiseasemodels.Priortopreparinganapplication,allapplicantsarestronglyencouragedtoconsultwithScientific/Researchstafftobeadvisedonappropriatenessoftheintendedresourceplansforthisprogram,competitivenessofapotentialapplication,andORIP'sprogrampriorities.">https://orip.nih.gov/about-orip</a>). This funding opportunity is designed to support both continuation of existing resources and to develop new ones when appropriate. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. Prior to preparing an application, all applicants are strongly encouraged to consult with Scientific/Research staff to be advised on appropriateness of the intended resource plans for this program, competitiveness of a potential application, and ORIP's program priorities.</p>
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<a id='_bookmark259602' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<div class=" col-md-8 datacolumn">
<p>The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).</p>
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<a id='_bookmark259603' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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<a id='_bookmark259604' tabindex='-1' aria-hidden='true'></a>Posted Date
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December 04, 2025
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<a id='_bookmark259605' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
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January 18, 2026
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<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">Earliest Start Date</th>
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<td>
February 18, 2026
</td>
<td>
February 18, 2026
</td>
<td>
May 11, 2026
</td>
<td>July 2026</td>
<td> October 2026
</td>
<td>December 2026</td>
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<td>
May 27, 2026
</td>
<td>
May 27, 2026
</td>
<td>
September 09, 2026
</td>
<td>November 2026</td>
<td> January 2027
</td>
<td>April 2027</td>
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<tr>
<td>
September 21, 2026
</td>
<td>
September 21, 2026
</td>
<td>
January 11, 2027
</td>
<td>March 2027</td>
<td> May 2027
</td>
<td>July 2027</td>
</tr>
<tr>
<td>
January 26, 2027
</td>
<td>
January 26, 2027
</td>
<td>
May 10, 2027
</td>
<td>July 2027</td>
<td> October 2027
</td>
<td>December 2027</td>
</tr>
<tr>
<td>
May 28, 2027
</td>
<td>
May 28, 2027
</td>
<td>
September 08, 2027
</td>
<td>November 2027</td>
<td> January 2028
</td>
<td>April 2028</td>
</tr>
<tr>
<td>
September 28, 2027
</td>
<td>
September 28, 2027
</td>
<td>
January 10, 2028
</td>
<td>March 2028</td>
<td> May 2028
</td>
<td>July 2028</td>
</tr>
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<td>
January 31, 2028
</td>
<td>
January 31, 2028
</td>
<td>
May 09, 2028
</td>
<td>July 2028</td>
<td> October 2028
</td>
<td>December 2028</td>
</tr>
<tr>
<td>
May 30, 2028
</td>
<td>
May 30, 2028
</td>
<td>
September 11, 2028
</td>
<td>November 2028</td>
<td> January 2029
</td>
<td>April 2029</td>
</tr>
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<td>
September 26, 2028
</td>
<td>
September 26, 2028
</td>
<td>
January 09, 2029
</td>
<td>March 2029</td>
<td> May 2029
</td>
<td>July 2029</td>
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<a id='_bookmark259609' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>
<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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<a id='_bookmark259615' tabindex='-1' aria-hidden='true'></a>Expiration Date
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<div class=" col-md-8 datacolumn">
January 10, 2029
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<p class="Normal">Not Applicable</p>
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<a id='_bookmark259617' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
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<p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. <b>Applications that do not comply with these instructions may be delayed or not accepted for review.</b></p>
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<a id='_bookmark262226' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li></ol>
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<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
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<a id='_bookmark259619' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
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<a id='_bookmark259620' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
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<a id='_bookmark259621' tabindex='-1' aria-hidden='true'></a><p><strong>Objective</strong></p><p>ORIP uses the P40 mechanism to support Animal and Biological Material Resource Centers in a variety of areas of biomedical science. Animal and Biological Material Resource Centers create, collect, develop, characterize, preserve, and distribute special colonies of high-quality and well-characterized laboratory animals and animal-related models. Special colonies of research animals are defined as animals that add value for biomedical research but are not generally available to investigators. Collecting, generating, and distributing such animals render these resources more accessible to the research community and eliminate costly redundant efforts. Other types of Animal and Biological Material Resource Centers provide informatics tools, data, analytical expertise, biological materials, or services that support research projects and that will enhance and expand an animal model system. Centers should emphasize use of broadly applicable, interdisciplinary validation tools to increase predictability of animal models, such as approaches to compare and determine relatedness and usefulness of a disease associated network/pathway/physiological process between an animal model and a human patient. Applications that heavily focus on building and maintaining genomic or phenotyping databases for individual animal species will not be considered for funding.</p><p>Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. NAMs enable research to be done more quickly, by more researchers, at a more affordable cost. Importantly, these advances are opening doors to complementary and more effective non-animal-based approaches for a variety of applications. The development of NAMs holds tremendous promise for increasing the tools available to achieve the NIH mission and potentially reduce and refine the future use of animals in some areas of research in the future. The Centers should promote integration with NAMs.</p><p>It is important that the community fully understand the strengths and limitations of these Centers, as well as areas of opportunity given the current state of science, that in turn will improve selection, design, and relevance of animal models.</p><p>Details concerning current Division of Comparative Medicine (DCM) Animal and Biological Material Resource Centers can be found at the following link: <a href="https://orip.nih.gov/resource-directory">https://orip.nih.gov/resource-directory</a>.</p><p>All applicants are strongly encouraged to consult with DCM Program staff on the appropriateness of the intended resource, competitiveness of a potential application, and whether the proposed application meets the goals and mission of the DCM/ORIP and is broad enough to serve the needs of the biomedical research community.</p><p>Examples of projects that WILL NOT be supported under this NOFO include those that:</p><ul><li>Focus on animal models and biomaterials that relate strictly to a specific disease or research area or are primarily relevant to the mission and programs of predominantly one NIH Institute or Center (IC). Examples of an inappropriate request are resources that exclusively maintain and distribute animals or biological materials for cancer, heart disease, or neurological disorders.</li><li>Do not serve investigators on a national basis.</li><li>Focus on distribution of wild-type animals and related biospecimens treated with diet, drug, toxin, infectious agents, or other environmental factors.</li><li>Distribute wild-type animals and related biospecimens subjected to physical or surgical manipulations.</li><li>Provide support for special colonies of threatened or endangered species.</li><li>Function exclusively or predominantly as a repository of specific tissues and related bio-specimens (i.e., RNA extracts, processed tissues) from model organisms.</li><li>Primarily involve human subjects, human cell lines, or related biological materials.</li></ul><p>Animal and Biological Material Resource Centers should have the following characteristics:</p><p>1) There should be a demonstrated need for the resource in the wider biomedical research community. Evidence of the depth and breadth of impact on a scientific community must be provided. Examples could include up to 15 letters of support from institutions, individuals, groups, or consortia; website usage; a statement from a scientific society; and/or a published white paper. Applications exceeding the 15 letters limit will be administratively withdrawn without review. Support letters from the institution submitting the P40 application are not counted towards this limit/cap.</p><p>2) The Centers should serve the needs of investigators in a variety of research areas where work is sponsored by multiple NIH ICs.</p><p>3) The Centers must be available and utilized by investigators on a national basis.</p><p>4) The Centers must ensure the quality and welfare of distributed animals and describe how their activities assist and promote optimization and enhancement of scientific rigor, transparency and experimental reproducibility of biomedical research.</p><p>5) The Centers must have an Applied Research Component to generate new approaches or to enhance existing ones that will improve the resources and services provided to the community. Hypothesis driven R21- or R01-like research is not considered applied research. Applied Research Component should include studies to generate comparative data to increase applicability of NAMs and promote integration of the most predictive human disease models. The Applied Research Component may comprise no more than 15 percent of the direct costs associated with the P40 grant.</p><p>6) The Centers must have a Curation and Informatics component to support development and maintenance of in-house data management systems, curate stocks of animals and biomaterials, and maintain a searchable web portal with an integrated client friendly request/ordering system and outreach presentations.</p><p>7) The Institution submitting the P40 application must be committed to the Center being proposed. Evidence of such support must be provided. The application should include a letter of support from the Institution.</p><p>8) A critical component of improving scientific reproducibility of the research is to develop approaches for unique identification of research resources in public databases, including publications. The Center should register catalogs of their resources with current resource tagging and identification initiatives, such as FORCE 11 (<a href="https://www.force11.org/group/resource-identification-initiative">https://www.force11.org/group/resource-identification-initiative</a>). The Center should also work with the investigators to encourage the use of a resource identification system in their publications and reports.</p><p>9) The Centers required to develop approaches to maintain critical resources in reliable and cost-effective ways. Long-term preservation of the genetic stock of animal models is needed to ensure efficiency, rigor, and reproducibility in biomedical research. Cryopreservation of the germplasm should be considered when it is appropriate. In addition, the Center should have a disaster preparedness plan to minimize total loss of resources in the event of a catastrophic disaster, such as loss of power or potable water, fire, flooding, data breach, pandemic or public health emergency.</p><p>10) The Center is required to develop an active program for monitoring and collecting information for reporting purposes and evaluating the impact of their ongoing activities and services provided to the biomedical community. Examples should include tracking user information (such as Institute affiliation and location), sources of funds, associated grant numbers for purchases made with Government funds, and/or outcomes of the studies using obtained animal models and biomaterials. Such information should also be included in progress reports to the NIH.</p><p><strong>Additional Information</strong></p><p>The P40 application is a multi-component application, with an Overall Component that is the aggregate of the Resource (major), Curation and Informatics (minor), and Applied Research (minor) Components.</p><p>Multiple PDs/PIs for the Overall grant are allowed. Typically, one or more of the PDs/PIs of the Overall application also serve as the Core Lead(s) of the Resource Component and can serve as the Project Lead(s) of the Curation and Informatics Component and/or Applied Research Component. The applied research is typically conducted at the applicant institution and not subcontracted.</p><p>It is required that Animal and Biological Material Resource Center grants will generate Program Income which will support efforts to enhance the volume of its operations. In general, this means that Renewal (a.k.a. Type 2) applications should recover in the initial year of the proposed grant cycle a greater percentage of operating costs from Program Income than for the last year of the previous grant cycle. Furthermore, each additional year in the proposed grant cycle should reasonably expect to recover a greater percentage of operating costs from Program Income than the average of the previous 5-year project period. Costs specifically associated with the establishment, improvement, or expansion of animal or material distributions and long-term resource maintenance should be recovered from users through a charge schedule acceptable to the NIH. Significant growth of Animal and Biological Material Resource Centers should result from Program Income and not from an ever-increasing P40 award. Note that the Center's use of Program Income is governed by the NIH Grants Policy statement, Section 8.3.2: (<a href="https://grants.nih.gov/grants/policy/policy.htm">http://grants.nih.gov/grants/policy/policy.htm</a>).</p><p>An important function of the Animal and Biological Material Resource Center is developing and maintaining the Center’s in-house data management systems in a format that may facilitate its integration with other animal resource databases and community standards for information accessibility and interoperability, and providing adequate staff for curation of newly acquired stocks for collection and animal resource distribution management. These activities will contribute to the implementation of the <a href="https://datascience.nih.gov/nih-strategic-plan-data-science">NIH Strategic Plan for Data Science</a>, which describes actions aimed at modernizing the biomedical research data ecosystem. Biomedical repositories should accept submission of relevant data from the community and generate its own data to store, organize, validate, archive, preserve, and distribute information in compliance with the FAIR (Findable, Accessible, Interoperable, and Reusable) Data Principles. Center should develop plans in accordance with the new NIH Policy for Data Management and Sharing (<a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-22-189.html">NOT-OD-22-189</a>) to better position itself for the updated data requirements. In addition, improving access to the Resource Center’s databases as well as developing metrics to evaluate the usage, utility, and impact of a given repository will improve the ability of the center to meet the needs of the biomedical research community.</p><p>Most Centers cannot afford to accept all possible donor deposits if the future demand for these materials cannot justify the expense associated with quality control, expansion and archiving of animals and biological materials. For this and additional reasons, Centers must have an External Advisory Board of experts and users who will be responsible for review and evaluation of the Center’s progress, guidance to the PDs/PIs on which potential new animals and biological materials should be accepted for archiving and future distribution, as well as analysis of the Center’s long-term sustainability, biomedical research relevance, and its ability to provide timely and relevant products and services to the research community. The assessments and recommendations should be provided annually to the PDs/PIs as well as NIH Program. The External Advisory Board must be composed of a minimum of 4 members (outside of the PI parent Institution) and must meet a minimum of once per year (the required expertise of the members should be stated, but names of the candidates should not be listed in the application). If a specific External Advisory Board member receives a salary from the P40 grant, s/he should be a non-voting member. Tele- or videoconferencing is encouraged to decrease costs unless the budgeted expense of face-to-face meetings is justified in the application.</p>
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<a id='_bookmark259624' tabindex='-1' aria-hidden='true'></a><p>See <a href="#">Section VIII. Other Information</a> for award authorities and regulations.</p>
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<a id='_bookmark259625' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
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<a id='_bookmark259626' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="259627" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark259627' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
New
<br>
Renewal
<br>
Resubmission
<br>
Revision
<br>
</div>
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<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark259629' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116"><font color="#0000ff">OER Glossary</font></a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provides details on these application types. Only those application types listed here are allowed for this NOFO.</p>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="259630" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark259630' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
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<p>Not Allowed: Only accepting applications that do not propose clinical trials.</p>
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<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark259631' tabindex='-1' aria-hidden='true'></a><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="259632" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark259632' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>The National Institutes of Health (<a href="http://www.nih.gov/">NIH</a>) intends to commit $1.3 M in FY 2023-2025 to fund at least two awards per fiscal year.</p>
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<a id='_bookmark259633' tabindex='-1' aria-hidden='true'></a>Award Budget
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<div class=" col-md-8 datacolumn">
<p>Application budgets are not limited but need to reflect the actual needs of the proposed project.</p><p>For Renewal (a.k.a. Type 2) applications including Renewal Resubmission applications, no more than a 5 percent increase of direct cost based on a previous non-competing year with the highest direct cost in the prior five-year funding cycle will be accepted. Those calculations do not include the budget for adding a new Curation and Informatics component (up to $300,000 of additional total cost per year) unless the renewal application already had a Curation and Informatics component added via a revision application or existing from the previous project period. In these cases, the 5 percent increase cap for direct cost includes this component.</p>
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<div class="col-md-4 datalabel" tabindex="0" data-element-id="259634" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark259634' tabindex='-1' aria-hidden='true'></a>Award Project Period
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<p class="Normal">The scope of the proposed project should determine the project period. The maximum project period is 5 years.</p>
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<a id='_bookmark259635' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
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<a id='_bookmark259636' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
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<a id='_bookmark259637' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
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<a id='_bookmark259638' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
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<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li></ul>
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<a id='_bookmark259639' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>
<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>
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<a id='_bookmark259642' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
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<a id='_bookmark259643' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organization) <strong>are not</strong> eligible to apply.</p>
</div>
<div data-element-id="259644" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark259644' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
</div>
<div data-element-id="259645" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark259645' tabindex='-1' aria-hidden='true'></a><p class="Normal">Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the NIH Grants Policy Statement</a>, <strong>are not</strong> allowed. </p>
</div>
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<a id='_bookmark259646' tabindex='-1' aria-hidden='true'></a>Required Registrations
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<p><strong>Applicant organizations</strong></p>
<p>Applicant organizations must complete and maintain the following registrations as described in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply- Appli
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