Advancing Global Health

DFOP0017890 Advancing Global Health APS

Annual Program Statement (APS)
Advancing Global Health
GHSD, Department of State
Opportunity number: DFOP0017890
Application deadline: Rolling, See Section E
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Contents
A. Basic Information ................................................................................................... 3
B. Eligibility ................................................................................................................ 4
C. Program Description ............................................................................................... 5
D. Application Contents and Format ............................................................................ 6
E. Submission Requirements and Deadlines ............................................................... 7
F. Application Review Information ............................................................................ 12
G. Post-Award Requirements and Administration ....................................................... 14
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U.S Department of State
Bureau of Global Health and Security (GHSD)
Annual Program Statement: Advancing Global Health
A. Basic Information
1. Overview
The Bureau of Global Health Security and Diplomacy (GHSD) of the U.S. Department of
State announces an open competition for organizations to implement a project (or projects) to
operationalize the American First Global Health Strategy.
As part of the Strategy, GHSD has pursued a bilateral, country-specific approach to advancing
U.S. global health priorities through the negotiation of Memoranda of Understanding (MOUs)
with partner governments. These MOUs articulate shared objectives, define mutual
commitments, and establish a framework for achieving concrete health outcomes and
advancing country self-reliance. It is expected that a critical implementation pathway for
these MOUs will be government-to-government (G2G) agreements, which will serve as an
important mechanism for delivering and sustaining many MOU-aligned activities.
This Annual Program Statement establishes a supplemental framework through which the
Department of State may identify and support projects that complement, extend, and/or fill
identified gaps in the implementation of these bilateral MOUs. Through specific Addenda,
the Department will signal priorities and needs. This APS provides the standard application
instructions for the submission of all Statements of Interest (SOIs) to these specific Addenda.
GHSD will collaborate with Embassies and other Department of State Bureaus and Offices to
post specific funding opportunities through Addenda to this APS that address health
challenges and priorities of importance.
Multiple awards may be made as a result of each Addendum of this APS. The actual number
of awards under each Addendum of this APS is subject to the availability of funds and the
viability of SOIs/applications received. Accordingly, the Department of State reserves the
right to award multiple awards, one award, or no awards at all under each Addendum.
Funding opportunity title Advancing Global Health
Funding opportunity number DFOP0017890
Announcement type Initial
Deadline for applications Rolling; see section E
Assistance listing number 19.029
Length of award performance period Up to 5 years
Number of awards anticipated Up to 100 awards
Award amounts Awards may range from a minimum of $500,000 to a
maximum of $250 million
Total estimated funding Up to $4.5 billion, subject to availability
Type of Funding Global Health Program Funds under the Foreign Assistance
Act
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The first step for interested applicants is the submission of a Statement of Interest (SOI), in
which applicants provide a concise concept note (described in Section D), describing a project
approach and intended outcomes. Importantly, SOIs should only be submitted in response to
specific Addenda, which present GHSD priorities (and will be issued throughout the year on
grants.gov). [Note: SOI that are not responsive to a specific Addendum will not be
considered]. The SOI is not a full application and will not result in a federal assistance award
at this step. Rather, the purpose of the SOI process is to allow applicants to submit project
ideas for evaluation prior to requiring the development of a full application. Upon a merit
review of eligible SOIs, selected applicants will be invited to develop a full application. If
needed, applicants may be invited to collaboratively design their project idea(s) with the
Department of State.
Funding Instrument Type: Grant or cooperative agreement. Cooperative agreements
include substantial involvement of the Department of State throughout implementation of the
project.
Award Performance Period: Proposed projects should be completed in five years or less.
The Department of State will consider applications for continuation grants funded under these
awards beyond the initial budget period but within the five year limitation on a non-
competitive basis subject to availability of funds, satisfactory progress of the award, and a
determination that continued funding would be in the best interest of the Department of State.
This notice is subject to availability of funding.
2. Executive Summary
The Department of State invites eligible applicants to advance the America First Global
Health Strategy through its new Advancing Global Health (AGH) program, which aims to
save lives, strengthen health systems, enhance efficiency, foster self-reliance, and ensure U.S.
investments benefit American safety, strength, and prosperity.
B. Eligibility
1. Eligible Applicants
The following organizations are eligible to apply:
• U.S. and foreign private for-profit enterprises
• U.S. and foreign public and private institutions of higher education
• U.S and foreign organizations, including faith-based organizations
• Public International Organizations (PIOs) and governmental institutions
2. Cost Sharing or Matching
Cost sharing or matching is not required. While applicants may propose cost share or
matching, cost-sharing/matching will not be evaluated as part of the merit review process.
Opportunities for cost sharing and matching may be discussed during negotiation and/or
consultative program design (aka “co-design”), if applicable. Per 2 CFR §200.306, items
that are proposed for cost share must be allowable per 2 CFR §200, Subpart E—Costs
Principles.
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3. Other Eligibility Requirements
Organizations are not required to obtain a Unique Entity Identifier (UEI) or be registered in
the System for Award Management (SAM.gov) in order to submit an SOI in phase 1.
However, all organizations must have a Unique Entity Identifier (UEI) issued via SAM.gov,
as well as a valid registration in SAM.gov before they submit a full application in phase 2.
Please see Section E for more information.
Any applicant listed on the Excluded Parties List System in the System for Award
Management in SAM.gov and/or has a current debt to the U.S. government is not eligible to
apply for an assistance award in accordance with the OMB guidelines at 2 CFR 180 that
implement Executive Orders 12549 (3 CFR,1986 Comp., p. 189) and 12689 (3 CFR,1989
Comp., p. 235), “Debarment and Suspension.”
Additionally, no entity or person listed on the Excluded Parties List System in SAM.gov can
participate in any activities under an award. All applicants are strongly encouraged to review
the Excluded Parties List System in SAM.gov to ensure that no ineligible entity or person is
included in their application.
C. Program Description
In September 2025, the Department of State released its America First Global Health Strategy,
which provides a detailed framework for advancing U.S. global health priorities while ensuring
that these efforts benefit the American people. As part of the America First Global Health
Strategy, the Department of State is entering into bilateral Memoranda of Understanding
(MOUs) with partner governments to define shared priorities, establish mutual commitments,
and achieve concrete health outcomes while advancing country self-reliance in national health
programs. It is expected that an important implementation pathway for these MOUs will be
government-to-government (G2G) agreements, which will serve as crucial mechanisms for
delivering and sustaining many MOU-aligned activities.
The Advancing Global Health (AGH) APS provides a mechanism to solicit and support projects
to complement existing activities and new G2G agreements, including where targeted technical,
operational, or catalytic support is needed to address gaps, sequencing challenges, or transitional
needs in MOU implementation. The Advancing Global Health Assistance activity will save lives,
strengthen health systems, enhance efficiency, foster self-reliance, and ensure that U.S.
investments in global health directly benefit American safety, strength, and prosperity.
Substantial Involvement
For awards that are issued as cooperative agreements, areas of substantial involvement include
(but are not limited) to the following:
• Joint Programmatic Decisions: The Department of State and the recipient collaborate
on key programmatic decisions. This can include (but is not limited to) reviewing work
plans; determining when certain phases of the project can start; and final method of
delivery or implementation.
• Technical Assistance and Direction: The Department of State provides ongoing
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technical assistance, guidance, and direction integral to the project's execution, which if
not followed, would undermine the goals and objectives of the award or otherwise make
the award unsuccessful.
D. Application Contents and Format
SOIs must be provided in response to specific Addenda issued under this APS. The Department
of State is under no obligation to review general concepts submitted under this umbrella APS or
to provide feedback for such submissions
1. Phase 1 – SOI
Please follow all instructions below carefully. SOIs that do not meet the requirements of this
announcement or fail to comply with the submission requirements will be deemed technically
ineligible and will not move forward to the Merit Panel Review (MRP). Contents of SOI
must include the following required information:
a. Table Listing of Critical Details:
I. Proposed Project Title
II. Name of the Organization
III. Addendum to which the SOI is responding
IV. Target Benefiting Country or Countries
V. Total Federal Share Requested
VI. Total Cost Share (as applicable)
VII. Project Length
b. Issue/Challenge/Opportunity: Briefly describe the problem(s), issue(s), challenge(s),
or opportunity(ies) the applicant is seeking to address.
c. Proposed Solution/Activities: Describe the approach and core activities to address the
issue/challenge/opportunity.
I. Anticipated Outcomes and Results: Identify the specific outcomes and results
the approach/activities seeks to achieve and define “success.” Outcomes and
results should aim to save lives, strengthen health systems, enhance efficiency,
foster self-reliance and ensure investments directly benefit American safety,
strength, and prosperity. Therefore, outcomes and results should clearly
demonstrate advancement towards the Department of State America First
Global Health Strategy. The nature, scope, and sustainability of outcomes and
results will be critical to assessing the costs and benefits – and determining
whether the SOI will proceed to the next stage of the merit review process.
d. List of Partner Roles and Responsibilities (if applicable): Include a list of proposed
applicant partners (private, public, NGO, etc.) to be considered as subrecipients (see 2
CFR 200.331 and 200.332). Identify organization name, point of contact, point of
contact information (phone and email), federal share to be award by the pass-through
entity, cost-share (if applicable), and a summary of proposed roles and responsibilities.
Note: This should be a brief, preliminary characterization of roles and responsibilities
that may evolve significantly during the subsequent phase.
e. Resource Contributions and/or Cost Share from non-federal sources (if applicable):
Describe how proposed resources will contribute to the proposed activities and
outcomes. This should be a preliminary description; actual resource contributions and
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applications may evolve significantly during the subsequent phase. Please reference 2
CFR 200.306(b) for guidance on what can be considered cost share.
The SOI is meant to convey initial ideas regarding a proposed project. As the negotiation
and/or consultative program design (if applicable) process continues, the ideas and approaches
may evolve as the applicant and the Department of State determine the most appropriate way
to work together to address the problems, challenges, issues, and opportunities.
Required Format of SOI Submission: All documents must be written in English, and all costs
must be presented in U.S. dollars. If an original document within the application is in another
language, an English translation must be provided (please note the Department of State, as
indicated in 2 CFR 200.111, requires that English is the official language of all award
documents). If any document is provided in both English and a foreign language, the English
language version is the controlling version. All pages must be numbered. Additional
requirements are as follows:
• All documents must be formatted to 8 ½ x 11 paper
• All documents must be single-spaced, written in a minimum of 12-point Times Roman
Numeral font with 1-inch margins.
o The exception is captions and footnotes which may be 10-point Times Roman
Numeral font. Font sizes in charts and tables, including the budget, can be
reformatted to fit within 1 page width.
• Submissions should be no more than 5 pages or 2500 words not inclusive of charts and
tables
E. Submission Requirements and Deadlines
1. Address to Request Application Package
Application forms and other materials necessary to apply are available at grants.gov (now
requires active sam.gov registration to apply) or MyGrants (does not require active
sam.gov registration to apply) under the announcement title “Advancing Global Health,”
funding opportunity number “DFOP0017890.”
Faxed, couriered, or emailed documents will not be accepted. Reasonable
accommodations may, in appropriate circumstances, be provided to applicants with
disabilities or for security reasons.
2. Department of State Contacts
If you have any questions about the grant application process, please contact:
GHSD-APS@state.gov
Questions and answers will be posted on grants.gov. Pre-Award Conferences may be held
via conference call or in-person throughout the rolling period. Questions and answers
from the pre-award conferences will also be posted on grants.gov.
3. UEI and SAM.gov Required Registrations
All organizations, whether based in the United States or in another country, must have a
UEI and an active registration in SAM.gov in order to submit a full proposal if they move
into phase 2. A UEI is one of the data elements mandated by Public Law 109-282, the
Federal Funding Accountability and Transparency Act (FFATA), for all Federal awards.
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An applicant must maintain an active registration while it has a proposal under review by
the Department and must continue to keep the registration active for the entire duration of
the period of performance of any Federal award that results from this NOFO. The 2 CFR
200 requires subrecipients to obtain a UEI. Please note the UEI for subrecipients is not
required at the time of application but will be required before an award is processed
and/or directed to a subrecipient.
Note: The process of obtaining or renewing a SAM.gov registration may take anywhere
from 4-8 weeks; please begin your registration as early as possible.
• Organizations based in the United States or that pay employees within the United
States will need an Employer Identification Number (EIN) from the Internal
Revenue Service (IRS) and a UEI prior to registering in SAM.gov.
• Organizations based outside of the United States and that do not pay employees
within the United States do not need an EIN from the IRS but do need a UEI prior
to registering in SAM.gov.
• Organizations based outside of the United States that do not intend to apply for
U.S. Department of Defense (DoD) awards are no longer required to have a
NATO Commercial and Government Entity (NCAGE) code to apply for non-DoD
foreign assistance funding opportunities. If an applicant organization is mid-
registration and wishes to remove an NCAGE code from their SAM.gov
registration, the applicant should submit a help desk ticket (“incident”) with the
Federal Service Desk (FSD) online at www.fsd.gov using the following language:
“I do not intend to seek financial assistance from the Department of Defense. I do
not wish to obtain an NCAGE code. I understand that I will need to submit my
registration after this incident is resolved in order to have my registration
activated.”
o Organizations based outside of the United States and that do not plan to do
business with the DoD should proceed to SAM.gov to obtain a UEI and
complete the SAM.gov registration process. SAM.gov registration must be
renewed annually.
o Organizations based outside of the United States and that do plan to do
business with the DoD in addition to Department of State should apply for an
NCAGE code by following the instructions on the NSPA NATO website
linked below:
NCAGE Homepage:
https://eportal.nspa.nato.int/AC135Public/sc/CageList.aspx
NCAGE Code Request Tool (NCRT):
NCAGE Code Request Tool (nato.int)
An exemption from the UEI and Sam.gov registration requirements may be permitted on
a case-by-case basis. See 2 CFR 25.110 for a full list of exemptions. Organizations
requesting exemption from UEI or SAM.gov requirements must email the point of
contact listed in the NOFO at least two weeks prior to the deadline in the NOFO
providing a justification of their request. Approval for a SAM.gov exemption must come
from the warranted Grants Officer before the application can be deemed eligible for
review.
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4. Submission Dates and Times
SOIs will be accepted on grants.gov (now requires active sam.gov registration to apply)
or MyGrants (does not require active sam.gov registration to apply) under the
announcement title “Advancing Global Health,” funding opportunity number
“DFOP0017890.” As a reminder, SOIs should only be submitted in response to specific
Addenda. Addenda will be posted during quarterly windows as follows:
• Window 1: March 5 – May 31; Applications due by 11:59 EST May 31
o Deadline for Questions: March 27
o Anticipated Response: April 13
• Window 2: June 1 – August 14; Applications due by 11:59 EST August 14
o Deadline for Questions: June 15
o Anticipated Response: July 3
• Window 3: August 15 – November 14; Applications due by 11:59 EST November 14
o Deadline for Questions: August 31
o Anticipated Response: September 21
• Window 4: November 15 – February 14; Applications due by 11:59 EST by February
14
o Deadline for Questions: November 30
In anticoipatAionnt iocfi pthaete qdu Raretseprloyn swei:n Ddoewcesm, tbheer S1t5ate Department will amend the APS to
include Addenda indicating specific areas, in which the U.S. government plans to invest.
5. Funding Restrictions
a. GHSD will not consider applications that reflect any type of support for any member,
affiliate, or representative of a designated terrorist organization. Please refer to the
link for Foreign Terrorist Organizations: https://www.state.gov/foreign-terrorist-
organizations/. Consistent with Department guidance on State Funding and the Risks
of Terrorist Financing for all State Department funded programs and requirements,
Department bureaus must assess the likelihood that the funds or Department funded
activities, goods, services, training, expert advice or assistance, or other benefits to be
provided, could inadvertently or incidentally benefit terrorist organizations or their
members or supporters, and must put in place appropriate risk mitigation measures to
mitigate such risk. In accordance with 14 FAM 247, and consistent with 2 FAM 050,
Counterterrorism (CT) name-check vetting may be performed in countries and
programs designated by the Department.
b. The Leahy Law prohibits Department foreign assistance funds from supporting
foreign security force units if the Secretary of State has credible information that the
unit has committed a gross violation of human rights. Per 22 USC §2378d(a) (2017),
“No assistance shall be furnished under this chapter [FOREIGN ASSISTANCE] or
the Arms Export Control Act [22 USC 2751 et seq.] to any unit of the security forces
of a foreign country if the Secretary of State has credible information that such unit
has committed a gross violation of human rights.” Restrictions may apply to any
proposed assistance to police or other law enforcement. Among these, pursuant to
section 620M of the Foreign Assistance Act of 1961, as amended (FAA), no
assistance provided through this funding opportunity may be furnished to any unit of
the security forces of a foreign country when there is credible information that such
unit has committed a gross violation of human rights. In accordance with the
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requirements of section 620M of the FAA, also known as the Leahy law, project
beneficiaries or participants from a foreign government’s security forces may need to
be vetted by the Department before the provision of any assistance. If a proposed
grant or cooperative agreement will provide assistance to foreign security forces or
personnel, compliance with the Leahy Law is required.
c. Funding Restrictions for the United Nations Relief and Works Agency (UNRWA):
None of the funds awarded resulting from this Notice of Funding Opportunity may be
made available for subawards, direct financial support, or otherwise used to provide
any payment or transfer to UNRWA.
d. Prohibition on Funding Activities that Encourage Mass-Migration Caravans towards
the United States Southwest Border: None of the funds awarded under this grant may
be made available to encourage, mobilize, publicize, or manage mass-migration
caravans towards the United States southwest border. Funds may not be made
available for legal counseling on the United States asylum process; and/or for
referrals to legal or representation in the United States. Funds may only be used for
cash cards for use in the country in which they are provided or to facilitate assisted
voluntary returns and other purposes that do not encourage, mobilize, publicize, or
manage mass migration caravans towards the United States southwest border. The
provision of humanitarian assistance is permitted.
e. Prohibition on Unmanned Aircraft Systems Manufactured or Assembled by American
Security Drone Act-Covered Foreign Entities
(a) Definitions.
American Security Drone Act-covered foreign entity means an entity included on
a list developed and maintained by the Federal Acquisition Security Council
(FASC) and published in the System for Award Management (SAM) at
https://www.sam.gov.
FASC-prohibited unmanned aircraft system means an unmanned aircraft
system manufactured or assembled by an American Security Drone Act-covered
foreign entity.
Unmanned aircraft means an aircraft that is operated without the possibility of
direct human intervention from within or on the aircraft.
Unmanned aircraft system means an unmanned aircraft and associated elements
(including communication links and the components that control the unmanned
aircraft) that are required for the operator to operate safely and efficiently in the
national airspace system.
(b) Prohibition. Recipients of funding under this Annual Program Statement
(including subawards and subcontracts) will be prohibited from:
(1) delivering any FASC-prohibited unmanned aircraft system, which
includes unmanned aircraft (i.e., drones) and associated elements;
(2) Operating a FASC-prohibited unmanned aircraft system in the performance
of the award (section 1824 of Pub. L. 118-31, 41 U.S.C. 3901 note prec.); and
(3) Using Federal funds for the purchase or operation of a FASC-
prohibited unmanned aircraft system.
(c) Exemptions, exceptions, and waivers. The prohibitions described above will not
apply if the agency determines that an exemption, exception, or waiver applies and
the award indicates that such a determination has been made. [See sections 1823
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through 1825 and 1832 of Public Law 118-31 ( 41 U.S.C. 3901 note prec.) for
statutory requirements pertaining to exemptions, exceptions, and waivers.].
f. Certification Regarding Compliance with applicable Federal anti-discrimination laws:
If the place of performance or delivery of any award made under this Statement of
Interest will be within the United States, applicants are advised that they will be
required to certify the following at the time of award:
o Its compliance in all respects with all applicable Federal anti-discrimination laws
is material to the government’s payment decisions for purposes of section
3729(b)(4) of title 31, United States Code and;
o It does not operate any programs promoting Diversity, Equity, and Inclusion that
violate any applicable Federal anti-discrimination laws. A program promoting
Diversity, Equity, and Inclusion means a program whose purpose is to promote
preferences based on race, color religion, sex, or national origins, such as in
training or hiring.
g. Certification Regarding Compliance with 20 U.S.C. 1011f and any other applicable
foreign funding disclosure requirements. Applicants are advised that IHEs must
certify the following at the time of award, and that this certification requirement must
be included in any subaward agreements to IHEs:
o Its compliance in all respects with section 1011f of title 20, United States Code,
and any other applicable foreign funding disclosure requirements is material for
purposes of section 3729 of title 31, United States Code, and for receipt of
appropriate Federal grant funds.
h. Certification of Trafficking in Persons Compliance and Compliance Plan: Applicants
are advised that they will be required to certify the following at the time of award for
awards where the estimated value of services to be performed outside the United
States exceeds $500,000:
o To the best of the Recipient’s knowledge, neither the Recipient, nor any
subrecipient, contractor, or subcontractor of the Recipient or any agent of the
recipient or of such a subrecipient, contractor, or subcontractor, is engaged in any
of the activities described in 2 CFR 175.105(a);
o The recipient has implemented a Trafficking in Persons compliance plan to
prevent activities described in 2 CFR 175(a) and is compliant with this plan; and
the compliance plan must follow the minimum requirements described in 2 CFR
175(b)(5).
o That the Recipient has and will implement procedures to prevent activities
described in 2 CFR 175.105(a) and to monitor, detect, and terminate any
subrecipient, contractor, subcontractor, or employee of the recipient engaging in
these activities.
Recipients do not need to submit a copy of the plan. However, they must provide it to
the Grants Officer upon request, and as appropriate, must post the useful and relevant
contents of the plan or related materials on its website and at the workplace.
Recipients must re-certify on an annual basis for the entire award period of
performance.
6. Other Submission Requirements
GHSD bears no responsibility for disqualification that result from applicants not being
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registered for submission before cycle due dates, for system errors, or other errors in the
application process.
GHSD encourages organizations to submit SOIs (or applications) during normal business
hours (Monday – Friday, 9:00AM - 5:00PM Eastern Standard Time [EST]). If an
applicant experiences technical difficulties and has contacted the appropriate helpdesk
but is not receiving timely assistance (e.g., if you have not received a response within 48
hours of contacting the helpdesk), you may contact the GHSD point of contact listed
above. The point of contact may assist in contacting the appropriate helpdesk.
Applicants using MyGrants for the first time will need their “New Organization
Registration.” To register with MyGrants, navigate to
https://MyGrants.servicenowservices.com and click “Create an Account” under “New User?”
On the pop-up, select “Create a MyGrants Applicant/Grantee Account” and complete all
required fields. Once completed, an email will be sent to verify the account creation
followed by an Okta Account set-up, which will require the use of a smartphone for
multi-factor authentication. If an applicant does not have accessibility to a smartphone
during the time of account creation, please contact the helpdesk at +1 (888) 313-4567
(toll charges apply for international callers) or through the self-service online portal that
can be accessed from ILMS Self Service Portal. Customer support is available 24/7.
F. Application Review Information
1. Review Criteria
Each submission will be evaluated and rated based on the following evaluation criteria:
• Quality of Program Idea: The SOI is responsive to both the APS framework and
Addendum priorities. The idea is communicated well and is feasible. SOI’s that promote
creative approaches to address program objectives are highly encouraged. The proposed
timeline is reasonable.
• Organizational Capacity and Record on Previous Grants: The SOI should
demonstrate the organization’s expertise and previous experience in administering
programs. If local partners are identified the SOI should briefly describe the partners’
roles and experience.
• Program Planning/Ability to Achieve Objectives: The SOI should clearly articulate
proposed program activities and expected results towards achieving program objectives
and goal(s).
2. Indirect Costs
If two or more applications receive equivalent scores based on the evaluation criteria outlined
in this NOFO, preference will be given to the applicant with the lower indirect cost rate, as
consistent with Executive Order 14332, Section 4(b)(iii). This preference will only be
applied as a tie-breaking mechanism and does not supersede the primary evaluation criteria.
3. Review and Selection Process
a. Phase 1- SOI Review and Selection:
All technically eligible SOIs will be reviewed against the criteria listed above by a GHSD
Merit Review Panel (MRP). [Note: SOIs not responsive to a specific Addendum will be
considered technically ineligible]. There may be multiple MRPs to review SOIs based on
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country, or region, as appropriate. SOIs will only be evaluated once. SOIs are reviewed
individually against the criteria and not against competing SOIs. Additionally, the MRP
will evaluate how the SOI meets the solicitation request, U.S. foreign policy goals, and
GHSD’s overall priority needs. For a fair review, all panelists will review the first page
of the SOI up to the page limit and no further. The MRP may provide conditions and/or
recommendations on SOIs to enhance the proposed program, which must be addressed by
the organization in the full application and/or co-design process, as applicable. To ensure
effective use of limited GHSD funds, conditions and recommendations may include
requests to increase, decrease, clarify, and/or justify costs and program activities.
GHSD reserves the right to make a final determination regarding all funding matters,
pending funding availability.
The panel is responsible for reviewing each SOI and recommending one of the following
actions:
i. SOI is not recommended for continued review – The concept is not responsive to
the APS and/or Addendum or the concept does not meet overall priority needs or
foreign policy.
ii. SOI is recommended for continued review through consultative program design
prior to recommendation for funding and submission of phase 2. The concept
meets a key (or emerging) priority or foreign policy goals that would benefit from
Department of State input. As a reminder, Addenda to the APS will be posted as
APS amendments highlighting Department of State priorities.
▪ GHSD will notify these applicants and assemble a team of subject matter
experts (SMEs) that may or may not include panel members. The
technical team and the applicant will work together to develop the concept
so that it can be recommended for funding and responsive to a request for
full proposal. All applicants within each evaluation panel will be treated
equally to ensure fair competition. If at least one applicant is
recommended to participate in consultative program design, all applicants
will be invited to participate. Consultative program design may be
individual with each organization, group, or a hybrid of both. The results
of the consultative program design process may or may not result in a
recommendation for funding and movement to phase 2. The Department
of State reserves the right to make this final determination. All costs to the
applicant associated with participation in the consultative program design
process will be at the expense of the applicant.
iii. SOI is recommended for funding and submission of phase 2 - The concept
outlines a well-tested approach that is ready to move to full application. An
amended negotiation letter will be issued to the applicant
Final selection of SOI concepts and funding authority resides with the GHSD senior
level official. All concepts must be approved before moving to phase 2.
Voting members of MRPs generally include representatives from GHSD policy and
program teams, and all MRP members sign non-disclosure agreements and conflict of
interest agreements. Additionally, Department of State often welcomes non-voting
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participation from interagency colleagues and other SMEs onto MRPs. Applications will
not be shared outside of the U.S. Government without the written consent of the
applicant.
b. Phase 2 – Request for full applications
Applicants that have moved either directly to phase 2 or subsequent to consultative
program design, will be directed to an announcement available via MyGrants to submit a
full application based on their approved concept. A full application typically includes but
is not limited to the following:
• SF-424, SF-424A, SF-424B (if applicable)
• Cover Page/Executive Summary
• Proposal Narrative
• Budget Narrative
• Program Monitoring and Evaluation Narrative and Plan
• Key Personnel
• Timeline
• Attachments, (if applicable)
Detailed instructions regarding the full application submission process will be provided
to those applicants that move to phase 2.
4. Risk Review
Under the merit review as required by 2 CFR 200.206, prior to making a Federal Award the
Department will review and consider the following risk factors:
I. Financial stability
II. Management systems and standards
III. History of performance
IV. Audit reports and findings
V. Ability to effectively implement requirements
VI. If there are any program specific risk factors that will be considered, describe
them here.
Prior to making award with a total amount of federal share greater than the simplified
acquisition threshold, the federal awarding agency is required to review and consider (see 41
U.S.C. 2313). An applicant can review and comment on any information in the
responsibility/qualification records available in SAM.gov. Before making decisions in the
risk review required by 2 CFR 200.206, the Department of State will consider any comments
by the applicant, along with information available in the responsibility/qualification records
in SAM.gov.
G. Award Notices
The grant award or cooperative agreement will be written, signed, awarded, and administered by
the Grants Officer (GO). The award agreement is the authorizing document, and it will be
provided to the recipient for review and signature by email. The recipient may only start
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incurring program expenses beginning on the start date shown on the grant award document
signed by the GO.
If an application is selected for funding, the Department of State has no obligation to provide any
additional future funding. Renewal of an award to increase funding or extend the period of
performance is at the discretion of the Department of State.
Issuance of this APS does not constitute an award commitment on the part of the U.S.
Government, nor does it commit the U.S. Government to pay for costs incurred in the
preparation and submission of proposals. Further, the U.S. Government reserves the right to
reject any or all proposals received.
H. Post-Award Requirements and Administration
1. Administrative and National Policy Requirements
Before submitting an application, applicants should review all the terms and conditions and
required certifications, which will apply to this award, to ensure that they will be able to
comply. In accordance with the Office of Management and Budget’s guidance in 2 CFR part
200, all applicable Federal laws, and relevant Executive guidance, the Department of State
will review and consider applications for funding, as applicable to specific programs,
pursuant to this NOFO in accordance with the following:
• Guidance for Grants and Agreements in Title 2 of the Code of Federal Regulations (2
CFR), as updated in the Federal Register’s 89 FR 30046 on April 22, 2024, particularly
on:
o Selecting recipients most likely to be successful in delivering results based on the
program objectives through an impartial process of evaluating Federal award
applications (2 CFR part 200.205),
o Promoting the freedom of speech and religious liberty in alignment with
Promoting Free Speech and Religious Liberty (E.O. 13798) and Improving Free
Inquiry, Transparency, and Accountability at Colleges and Universities (E.O.
13864) (§§ 200.300, 200.303, 200.339, and 200.341),
o Providing a preference, to the extent permitted by law, to maximize use of goods,
products, and materials produced in the United States (2 CFR part 200.322), and
o Terminating agreements pursuant to the Department of State Standard Terms and
Conditions, including, to the greatest extent authorized by law, if an award no
longer effectuates the program goals or agency priorities (2 CFR part 200.340).
• 2 CFR 25 - UNIVERSAL IDENTIFIER AND SYSTEM FOR AWARD
MANAGEMENT
• 2 CFR 170 - REPORTING SUBAWARD AND EXECUTIVE COMPENSATION
INFORMATION
• 2 CFR 175 - AWARD TERM FOR TRAFFICKING IN PERSONS
• 2 CFR 182 - GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE
WORKPLACE (FINANCIAL ASSISTANCE)
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• 2 CFR 183 - NEVER CONTRACT WITH THE ENEMY
• 2 CFR 600 – DEPARTMENT OF STATE REQUIREMENTS
• U.S. DEPARTMENT OF STATE STANDARD TERMS AND CONDITIONS
2. Reporting
Recipients will be required to submit financial reports and program performance reports.
The award document will specify what reports are required and how often these reports must
be submitted.
Foreign Assistance Data Review: As required by Congress, the Department of State must
make progress in its efforts to improve tracking and reporting of foreign assistance data
through the Foreign Assistance Data Review (FADR). The FADR requires tracking of
foreign assistance activity data from budgeting, planning, and allocation through obligation
and disbursement. Successful applicants will be required to report and draw down federal
funding based on the appropriate FADR Data Elements, indicated within their award
documentation. In cases of more than one FADR Data Element, typically program or sector
and/or regions or country, the successful applicant will be required to maintain separate
accounting records.
Applicants should be aware of the post award reporting requirements reflected in 2 CFR 200
Appendix XII—Award Term and Condition for Recipient Integrity and Performance Matters.
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DFOP0017890 GHSD Advancing Global Health APS Child Protection Addendum

Annual Program Statement Addendum
Child Development, Care, and Protection
U.S Department of State
Bureau of Global Health and Security and Diplomacy (GHSD)
A. Basic Information
1. Overview
The Bureau of Global Health Security and Diplomacy (GHSD) of the U.S. Department of State
invites organizations to submit a statement of interest (SOI) to carry out a project (or projects) to
measurably improve the safety, development and well-being of children in highly vulnerable
situations, particularly those who are living without adequate family care.
The purpose of this addendum is to indicate specific areas where the Department of State would
like to receive statements of interest. Submission instructions are included in the “Advancing
Global Health” Annual Program Statement (APS). The submission of the SOI is the first step in
a two-step process. Applicants must first submit a concise SOI clearly communicating project
ideas and objectives. Importantly, this is not a full proposal and will not result in a federal
assistance award at this step.
The purpose of the SOI process is to allow applicants to submit project ideas for evaluation prior
to requiring the development of a full proposal application.
Funding Opportunity Title Advancing Global Health
Funding Opportunity Number DFOP0017890
Addendum Title Child Development, Care and Protection
Deadline for Questions 11:59 pm EST March 27
SOI Due Date 11:59 pm EST May 31
Number of awards anticipated Up to 5
Total available funding Up to $52,650,000 pending funding availability
Project Performance Period: Proposed projects should be completed in five years or less.
This notice is subject to availability of funding.
As noted in the “Advancing Global Health” APS, the Department of State may opt to utilize a
consultative program design process for certain Addenda. SOIs submitted under this Addendum
may be recommended for continued review through consultative program design prior to
recommendation for funding and submission of phase 2. Additional details about the
consultative program design process can be found in the main APS document within Section F:
“Application Review Information.”
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2. Executive Summary
The Department of State invites interested organizations to submit SOIs to address the needs of
children vulnerable to violence, exploitation, abuse, and neglect, and to promote safe, nurturing
family environments for children worldwide. This programming aims to align with global best
practices, prioritizing a child-centered approach that strengthens families and child protection
systems, while expanding the availability and quality of family-based care options where
necessary. The anticipated projects under this Addendum will support government partners and
local organizations develop the social service workforce to provide essential services to children
and families. Successful SOIs will demonstrate a clear understanding of systemic vulnerabilities
and propose evidence-based interventions to improve child well-being outcomes. In doing so,
this Addendum ensures U.S. foreign assistance delivers measurable results that protect
vulnerable children, strengthen families, and promote stability in partner countries – contributing
to safer, more self-reliant societies that align with U.S. interests and values.
B. Program Description
The prevalence of child abuse, exploitation, and neglect poses a significant global threat to child
safety and development. Many countries lack the comprehensive national and local systems
required to adequately protect children and respond effectively to their needs. In addition, early
childhood is a critical stage of human development, with 90% of brain development occurring by
age 5. Promoting developmental stimulation in conjunction with nutrition and health services is
cost-effective and results in better outcomes for children than either alone. This Addendum is
designed to support family strengthening and approaches to promote children’s development,
care and protection, focusing on both prevention and response. It also seeks to move away from
outdated models of residential care by investing in family-based alternatives where required,
such as foster care and kinship care. The Department of State, through the Bureau of Global
Health Security and Diplomacy (GHSD), is committed to partnering with organizations that can
drive sustainable, long-term systemic change that ensures every child can grow up in a safe,
nurturing, and protective family. Such efforts are aligned with the America First foreign policy
vision for foreign assistance, outlined in the Department’s Agency Strategic Plan (FY26-30), and
advance this Administration’s commitment to protecting children at all stages of life and
promoting family values.
1. Goals and Objectives
The topline goal of this Addendum is to significantly improve the safety and well-being of
vulnerable children and their families globally by strengthening national child protection systems
and approaches that promote children’s development, care, and protection, focusing on both
prevention and response.
Objective 1: Strengthen Child Protection Systems: Develop and implement effective laws
and policies to prevent and respond to violence, exploitation, abuse, and neglect, including
online risks, trafficking, child marriage, and child labor. Support the frontline workforce
serving extremely vulnerable children and families. This involves building the capacity of
the social service workforce to identify vulnerable children experiencing harm or separation
and provide emergency and supportive response services, including case management,
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temporary care (foster or kinship), family reunification, medical care, and assistance with
basic and life-saving needs.
Objective 2: Implement comprehensive programs to prevent malnutrition and poor
development during the critical 1,000 days (conception to age two), including interventions
fostering secure, stimulating parent-child relationships. Provide intensive services for the
most vulnerable parents and children via referral mechanisms and home-visiting programs
offering integrated support: health, nutrition, nurturing care, family/economic strengthening,
and psychosocial support.
Objective 3: Prevent child-family separation and reduce reliance on residential care:
Implement evidence-based family strengthening programs focusing on economic
empowerment, parental skill-building, and connecting vulnerable families to social services
to keep children safely with their families. Where needed, expand and improve family-based
care by increasing the availability and quality of safe and monitored family-based options,
such as foster and kinship care and other care reform measures.
2. Guiding Principles
This Addendum is guided by principles ensuring all programming is ethical, sustainable, and
child-centered:
• Child-Centered, Trauma-Informed, and 'Do No Harm': All interventions must prioritize
the best interest of the child and safeguard children from potential harm.
• Capacity Building and Sustainability: Programming must focus on strengthening the
capacity of local and national partners, including national governments where appropriate
and feasible, ensuring that systems and services remain effective long after the project
period ends.
• Evidence-Based and Adaptable: Proposed activities must be informed by the best
available evidence and adapted to the specific cultural and policy context of the host
country.
• Coordination and Collaboration: Activities should be coordinated with other
international and national actors, including relevant UN agencies and local organizations,
to avoid duplication and maximize collective impact on child development, care and
protection
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DFOP0017890 GHSD Advancing Global Health APS Outbreak Response Addendum

Annual Program Statement Addendum
Rapid Outbreak Response
U.S Department of State
Bureau of Global Health and Security and Diplomacy (GHSD)
A. Basic Information
1. Overview
The Bureau of Global Health Security and Diplomacy (GHSD) of the U.S. Department of State
invites organizations to submit a statement of interest (SOI), proposing a project (or projects) to
support countries with comprehensive responses to infectious disease outbreaks.
The purpose of this addendum is to indicate specific areas where the Department of State would
like to receive SOIs. Submission instructions are included in the “Advancing Global Health”
Annual Program Statement (APS). The submission of the SOI is the first step in a two-step
process, in which applicants must first submit a concept note that presents a project approach and
intended outcomes. Importantly, this is not a full application and will not result in a federal
assistance award at this step. This Addendum will not include a consultative program design
phase.
The purpose of the SOI process is to allow applicants to submit project ideas for evaluation prior
to requiring the development of a full proposal application.
Funding opportunity title Advancing Global Health
Funding Opportunity Number DFOP0017890
Addendum title Rapid Outbreak Response
Deadline for Questions 11:59 pm EST March 27
SOI Due Date 11:59 pm EST May 31
Number of awards anticipated Up to 10 awards
Total estimated funding Up to $290M, subject to availability
Proposed projects should be completed in five years or less.
This notice is subject to availability of funding.
2. Executive Summary
The Department of State invites eligible U.S. and foreign organizations to advance the rapid
outbreak response (ROR) efforts in line with Pillar One of the America First Global Health
Strategy, Making America Safer, and its Goals: Goal 1: Enable detection of an outbreak with
epidemic potential within seven days of its emergence; and Goal 2: Contain outbreaks that
originate outside of the United States rapidly at their source. ROR efforts will advance the
United States’ work to contain outbreaks and prevent pandemics, activities which are critical to

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protecting Americans and safeguarding our economy. By containing outbreaks before they reach
American shores, the United States is able to protect its economy and the health of Americans
both at home and abroad.
B. Program Description
The Department of State is announcing the launch of the Rapid Outbreak Response (ROR)
projects, in line with the America First Global Health Strategy, to advance programming that
enable timely, effective responses to infectious disease outbreaks by supporting immediate
response actions during the earliest stages of an outbreak when rapid intervention can
significantly limit transmission and reduce morbidity and mortality. These ROR efforts will
capitalize on existing country capacities and partnerships to support swift activation of outbreak
response activities, complementing national leadership and established response frameworks.
Projects supported under this addendum will prioritize speed, operational readiness, and
flexibility, enabling countries to respond rapidly to evolving epidemiological threats, while
maintaining coordination across national, regional, and international actors.
ROR projects will provide life-saving response support across key technical and operational
domains, which may include (but are not limited to) coordination and incident management
support; point of entry screening and border health measures; medical countermeasures;
immunization for outbreak prevention and response; nutrition crisis prevention; infection
prevention and control; case management; laboratory strengthening; surveillance and data
collection and use; and operational and logistical support. Activities are expected to be time-
bound, surge-oriented, culturally adapted and scalable, allowing partners to adapt interventions
as outbreak dynamics change.
At the same time, ROR programming will reinforce and invest in critical country systems for
detecting, responding to, and managing outbreaks, helping to ensure that rapid response efforts
contribute to sustained national and global health security and health system resilience. Projects
supported under this addendum should demonstrate operational feasibility in high-risk
environments and the ability to transition seamlessly from emergency response to recovery or
longer-term capacity strengthening, as appropriate.
1. Goals and Objectives
In line with the America First Global Health Strategy, the goal of these projects is to enable
rapid, effective, and coordinated outbreak response actions that contain infectious disease threats,
reduce morbidity and mortality, and limit cross-border spread during the earliest stages of an
outbreak. Proposed projects can focus on one Objective or cover several of the Objectives listed
below.
Objective 1: Rapid Activation and Surge Response
Enable the immediate mobilization of technical, operational, and logistical capacities to
support countries responding to emerging or re-emerging infectious disease outbreaks,
particularly within the first days and weeks of detection.
Objective 2: Early Detection, Containment, and Mitigation
Strengthen short-term response interventions that support timely detection, surveillance, and

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containment of outbreaks, including infection prevention and control, case management,
immunization outbreak response, nutrition crisis prevention, community-based surveillance,
risk communication, laboratory services, and point of entry screening.
Objective 3: Coordinated and Operationally Effective Response
Support effective coordination and incident management across national authorities,
implementing partners, and other stakeholders to ensure aligned, efficient, and risk-informed
outbreak response operations.
Objective 4: System Reinforcement and Transition
Reinforce critical country systems for outbreak detection and response while enabling a
smooth transition from emergency surge activities to recovery or longer-term resilience and
capacity-building efforts, as appropriate.
2. Guiding Principles
Projects supported under the Rapid Outbreak Response (ROR) Addendum will be guided by the
principles outlined in the America First Global Health Strategy, emphasizing targeted, results-
driven investments that protect the health and security of the American people while
strengthening partner countries’ ability to prevent, detect, respond to, and recover from
infectious disease threats.
• Speed, Precision, and Operational Readiness: Interventions must prioritize rapid
activation and execution, particularly during the earliest stages of an outbreak. Projects
should demonstrate operational readiness, streamlined decision-making, and the ability
to deploy technical and logistical support quickly in high-risk, dynamic environments.
• Country Ownership and Sovereignty: Consistent with the America First Global Health
Strategy, activities should support and reinforce host-country leadership, national
response plans, and sovereign decision-making. ROR investments are intended to
complement (and not replace) country government-led efforts and should strengthen
national capacities to manage outbreaks effectively.
• Targeted, High-Impact Use of Resources: Projects should focus on clearly defined,
time-bound interventions that deliver measurable impact. ROR prioritizes efficient use
of U.S. government resources, directing funding toward actions that demonstrably
reduce transmission, morbidity, and mortality and mitigate cross-border health risks.
• Risk-Based and Evidence-Informed Decision Making: Projects should be grounded in
real-time epidemiological data, risk assessments, and operational intelligence.
Applicants are expected to adapt interventions as outbreak conditions evolve, applying
evidence-informed approaches to maximize effectiveness and minimize unintended
consequences.
• Coordination and Accountability: Effective outbreak response requires close
coordination across national and sub-national governments, implementing partners, and
other stakeholders. ROR projects must demonstrate clear roles, responsibilities, and
accountability mechanisms to ensure coherent action and responsible stewardship of
U.S. Government funds.
• Sustainability and Transition: While ROR projects are designed to address urgent
response needs, they should also reinforce critical systems for outbreak detection and
response. Projects should facilitate a smooth transition from emergency surge activities

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to recovery, stabilization, or longer-term capacity strengthening where appropriate,
consistent with U.S. strategic priorities.