Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

Q: How much funding does Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional) provide?

Funding amounts vary. Check the grant details for specifics.

Q: When is the deadline for Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)?

The deadline is November 30, 2028.

Overview

Current recipients of specific types of NIH research grants may apply for administrative supplements, using this Notice of Funding Opportunity (NOFO), to provide additional funding to a currently funded grant to meet increased costs that are within the scope of the peer-reviewed and approved project, but that were unforeseen when the new or competing renewal application was awarded. Applications for administrative supplements are considered prior approval requests (as described in Section 8.1.2.11 of the NIH Grants Policy Statement) and will be routed directly to the Grants Management Officer of the parent award. There is no guarantee that funds are available from the awarding IC or for any specific grant. Therefore, prior to submission, applicants must discuss potential requests with the awarding ICO grants and program officials.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: PA-26-001
Instrument: grant

Eligibility

Other Eligible Applicants: Indian/Native American Tribal Governments (Other than Federally Recognized); Eligible Agencies of the Federal Government; U.S. Territory or Possession; Faith-based or Community-based Organizations; Regional Organizations; Non-domestic (non-U.S.) Entities (Foreign Organizations). Reminder: This NOFO supports administrative supplements to existing projects. To be eligible, the parent award must be active (i.e., not in a co-cost extension), and the research proposed in the supplement must be accomplished within the competitive segment. The proposed supplement must be to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the scope of the peer reviewed and approved project. IMPORTANT: The research proposed in the supplement application must be within the peer-reviewed scope of the NIH-supported grant project. Foreign Organizations/International Collaborations: All activities with foreign institutions must align wi

Eligibility

Eligible Applicant Types

for_profit_organizations_other_than_small_businessescounty_governmentssmall_businessespublic_and_indian_housing_authoritiesother_native_american_tribal_organizationsindependent_school_districtsprivate_institutions_of_higher_educationcity_or_township_governmentsstate_governmentsnonprofits_non_higher_education_with_501c3nonprofits_non_higher_education_without_501c3public_and_state_institutions_of_higher_educationspecial_district_governmentsfederally_recognized_native_american_tribal_governmentsother

How to Apply

PA-26-001-Full-Announcement.html

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<title>PA-26-001: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

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<div data-element-id="268243" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268243' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark268244' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
</div>
<div class=" col-md-8 datacolumn">
<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
</div>
</div>

<div class="row" data-index="4">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268246" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268246' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
</div>
<div class=" col-md-8 datacolumn">
<p>NATIONAL INSTITUTES OF HEALTH (<a href="https://www.nih.gov/" target="_blank" rel="noreferrer">NIH</a>)
<p>National Eye Institute (<a href="https://www.nei.nih.gov/" target="_blank" rel="noreferrer">NEI</a>)
</p>
<p>National Heart, Lung, and Blood Institute (<a href="https://www.nhlbi.nih.gov/" target="_blank" rel="noreferrer">NHLBI</a>)
</p>
<p>National Human Genome Research Institute (<a href="https://www.genome.gov/" target="_blank" rel="noreferrer">NHGRI</a>)
</p>
<p>National Institute on
Aging (<a href="https://www.nia.nih.gov/" target="_blank" rel="noreferrer">NIA</a>)
</p>
<p>National Institute on Alcohol Abuse and Alcoholism (<a href="https://www.niaaa.nih.gov/" target="_blank" rel="noreferrer">NIAAA</a>)
</p>
<p>National Institute of Allergy and Infectious Diseases (<a href="https://www.niaid.nih.gov/" target="_blank" rel="noreferrer">NIAID</a>)
</p>
<p>National Institute of Arthritis and Musculoskeletal and Skin Diseases (<a href="https://www.niams.nih.gov/" target="_blank" rel="noreferrer">NIAMS</a>)
</p>
<p>National Institute of Biomedical Imaging and Bioengineering (<a href="https://www.nibib.nih.gov/" target="_blank" rel="noreferrer">NIBIB</a>)
</p>
<p>National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/" target="_blank" rel="noreferrer">NIDCD</a>)
</p>
<p>National Institute of Dental and Craniofacial Research (<a href="https://www.nidcr.nih.gov/" target="_blank" rel="noreferrer">NIDCR</a>)
</p>
<p>National Institute of Diabetes and Digestive and Kidney Diseases (<a href="https://www.niddk.nih.gov/" target="_blank" rel="noreferrer">NIDDK</a>)
</p>
<p>National Institute on Drug Abuse (<a href="https://www.drugabuse.gov/" target="_blank" rel="noreferrer">NIDA</a>)
</p>
<p>National Institute of Environmental Health Sciences (<a href="https://www.niehs.nih.gov/" target="_blank" rel="noreferrer">NIEHS</a>)
</p>
<p>National Institute of General Medical Sciences (<a href="https://www.nigms.nih.gov/" target="_blank" rel="noreferrer">NIGMS</a>)
</p>
<p>National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml" target="_blank" rel="noreferrer">NIMH</a>)
</p>
<p>National Institute of Neurological Disorders and
Stroke (<a href="https://www.ninds.nih.gov/" target="_blank" rel="noreferrer">NINDS</a>)
</p>
<p>National Institute of Nursing Research (<a href="https://www.ninr.nih.gov/" target="_blank" rel="noreferrer">NINR</a>)
</p>
<p>National Institute on Minority Health and Health Disparities (<a href="https://www.nimhd.nih.gov/" target="_blank" rel="noreferrer">NIMHD</a>)
</p>
<p>National Library of Medicine (<a href="https://www.nlm.nih.gov/" target="_blank" rel="noreferrer">NLM</a>)
</p>
<p>Fogarty International Center (<a href="https://www.fic.nih.gov/Pages/Default.aspx" target="_blank" rel="noreferrer">FIC</a>)
</p>
<p>National Center for Complementary and Integrative Health (<a href="https://nccih.nih.gov/" target="_blank" rel="noreferrer">NCCIH</a>)
</p>
<p>National Center for Advancing Translational Sciences (<a href="https://ncats.nih.gov/" target="_blank" rel="noreferrer">NCATS</a>)
</p>
<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (<a href="https://orip.nih.gov/" target="_blank" rel="noreferrer">ORIP</a>)
</p>
<p>Office of Strategic Coordination (<a href="https://commonfund.nih.gov/" target="_blank" rel="noreferrer">Common Fund</a>)
</p>
<p>National Cancer Institute (<a href="https://www.cancer.gov/" target="_blank" rel="noreferrer">NCI</a>)
</p>
<p>Office of The Director, National Institutes of Health (<a href="https://www.nih.gov/institutes-nih/nih-office-director" target="_blank" rel="noreferrer">OD</a>)
</p>

<p>All applications to this funding opportunity announcement should fall within the mission of the Institutes/Centers. The following NIH Offices may co-fund applications assigned to those Institutes/Centers.
</p>
<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (<a href="https://prevention.nih.gov/" target="_blank" rel="noreferrer">ODP</a>)
</p>
<p>Office of Behavioral and Social Sciences Research (<a href="https://obssr.od.nih.gov/" target="_blank" rel="noreferrer">OBSSR</a>)
</p>
<p>Office of Dietary Supplements (<a href="https://ods.od.nih.gov/" target="_blank" rel="noreferrer">ODS</a>)
</p>
<p>Office of Research on Women's Health (<a href="https://orwh.od.nih.gov/" target="_blank" rel="noreferrer">ORWH</a>)
</p>
</div>
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<a id='_bookmark268248' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
</div>
<div class=" col-md-8 datacolumn">
<span class="title">Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)</span>
</div>
</div>

<div class="row" data-index="7">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268249" data-element-required="true" data-element-has-value="false" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268249' tabindex='-1' aria-hidden='true'></a>Activity Code
</div>
<div class=" col-md-8 datacolumn">

</div>
</div>

<div class="row" data-index="8">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268250" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268250' tabindex='-1' aria-hidden='true'></a>Announcement Type
</div>
<div class=" col-md-8 datacolumn">
Reissue of

<a href="https://grants.nih.gov/grants/guide/pa-files/PA-20-272.html" target="_blank" rel="noreferrer">PA-20-272</a>

<br/>
</div>
</div>

<div class="row" data-index="9">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268251" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268251' tabindex='-1' aria-hidden='true'></a>Related Notices
</div>
<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements. </li></ul>
</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268252" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268252' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
</div>
<div class=" col-md-8 datacolumn">
<span class="noticenum">PA-26-001</span>
</div>
</div>

<div class="row" data-index="11">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268253" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268253' tabindex='-1' aria-hidden='true'></a>Companion Funding Opportunity
</div>
<div class=" col-md-8 datacolumn">
None
</div>
</div>

<div class="row" data-index="12">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268254" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268254' tabindex='-1' aria-hidden='true'></a>Number of Applications
</div>
<div class=" col-md-8 datacolumn">
<p>See Section III. 3. Additional Information on Eligibility.</p>
</div>
</div>

<div class="row" data-index="13">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268255" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268255' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
</div>
<div class=" col-md-8 datacolumn">
93.310, 93.866, 93.839, 93.273, 93.855, 93.846, 93.286, 93.847, 93.113, 93.142, 93.143, 93.350, 93.989, 93.393, 93.394, 93.395, 93.396, 93.399, 93.867, 93.172, 93.233, 93.837, 93.838, 93.859, 93.242, 93.307, 93.853, 93.361, 93.879, 93.351, 93.313, 93.173, 93.213, 93.372, 93.840, 93.279, 93.121
</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268256" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268256' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Purpose
</div>
<div class=" col-md-8 datacolumn">
<p data-suggestion-start-before="insertion:e498913637ca8536558cc0a2a00c6624f:WALTERSM_862">Current recipients of specific <a href="https://grants.nih.gov/funding/activity-codes">types of NIH research grants</a> may apply for administrative supplements, using this Notice of Funding Opportunity (NOFO), to provide additional funding to a currently funded grant to meet increased costs that are within the scope of the peer-reviewed and approved project, but that were unforeseen when the new or competing renewal application was awarded. Applications for administrative supplements are considered prior approval requests (as described in <a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_8/8.1_changes_in_project_and_budget.htm#Need">Section 8.1.2.11 of the NIH Grants Policy Statement</a>) and will be routed directly to the Grants Management Officer of the parent award. There is no guarantee that funds are available from the awarding IC or for any specific grant. Therefore, <strong>prior to submission, applicants must discuss potential</strong> <strong>requests with the awarding ICO grants and program officials.</strong> </p>
</div>
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<div class="row" data-index="15">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268257" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark268257' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
</div>
<div class=" col-md-8 datacolumn">
<p>NIHs mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.</p><p>See the <a href="https://www.nih.gov/about-nih/mission-goals">NIH Mission Statement</a> and the <a href="https://www.nih.gov/about-nih/nih-director/statements/advancing-nihs-mission-through-unified-strategy">NIH Directors Statement of Priorities</a>, entitled Advancing NIHs Mission Through a Unified Strategy. </p>
</div>
</div>

<div data-element-id="268258" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268258' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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<a id='_bookmark268259' tabindex='-1' aria-hidden='true'></a>Posted Date
</div>
<div class=" col-md-8 datacolumn">

</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268260" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268260' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
</div>
<div class=" col-md-8 datacolumn">
December 01, 2025
</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268261" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268261' tabindex='-1' aria-hidden='true'></a>Application Due Date(s)
</div>
<div class=" col-md-8 datacolumn">
<p>Due dates may vary by awarding IC. See <a href="https://grants.nih.gov/funding/funding-categories/supplemental-funding/administrative-supplements">Administrative Supplements</a> on the <a href="https://grants.nih.gov/">NIH Grants & Funding</a> site for IC-specific information including any special due dates. Applicants may also contact their respective awarding IC.</p>
</div>
</div>

<div class="row" data-index="20">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark268262' tabindex='-1' aria-hidden='true'></a><p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268263" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268263' tabindex='-1' aria-hidden='true'></a>AIDS Application Due Date(s)
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="row" data-index="22">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268264" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268264' tabindex='-1' aria-hidden='true'></a>Scientific Merit Review
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="row" data-index="23">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268265" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268265' tabindex='-1' aria-hidden='true'></a>Advisory Council Review
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="row" data-index="24">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268266" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268266' tabindex='-1' aria-hidden='true'></a>Earliest Start Date
</div>
<div class=" col-md-8 datacolumn">
<p>Earliest start dates vary by awarding IC. </p>
</div>
</div>

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<div class="col-md-4 datalabel" tabindex="0" data-element-id="268267" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark268267' tabindex='-1' aria-hidden='true'></a>Expiration Date
</div>
<div class=" col-md-8 datacolumn">
November 30, 2028
</div>
</div>

<div class="row" data-index="26">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268268" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268268' tabindex='-1' aria-hidden='true'></a>Due Dates for E.O. 12372
</div>
<div class=" col-md-8 datacolumn">
<p>Not Applicable</p>
</div>
</div>

<div class="heading4" tabindex="0" data-element-id="268269" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268269' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
</div>

<div data-element-id="268269" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<p>It is critical that applicants follow the instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, as appropriate except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.</p>
</div>

<div data-element-id="268348" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark268348' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li><li>Use <a href="https://grants.gov/search-grants?oppStatuses=closed|archived|posted|forecasted&fon=PA-25-301">Grants.gov</a> Workspace to prepare and submit your application and <a href="http://public.era.nih.gov/commons/">eRA Commons</a> to track your application.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

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<a id='_bookmark268271' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>

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<a id='_bookmark268272' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>

<div data-element-id="268273" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark268273' tabindex='-1' aria-hidden='true'></a><p data-suggestion-start-before="insertion:ec12b79d0f6728c5ccacef2e92c136123:WALTERSM_862">Definition: An administrative supplement (Type 3) is a request for additional funds during a current project period to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the current scope of the peer reviewed and approved project and the activities must not extend beyond the term of the current award. Administrative supplements do not require peer review.</p><p>Potential indicators of a <strong>change</strong> of scope include but are not limited to:</p><ul><li>Change in the specific aims approved at the time of award</li><li>Change from non-human subject research to research involving human subjects</li><li>Shift of the research emphasis from one disease area to another</li></ul><p>Administrative supplements are used for a variety of unforeseen circumstances. See <a href="https://grants.nih.gov/funding/funding-categories/supplemental-funding/administrative-supplements">Administrative Supplements</a> on the <a href="https://grants.nih.gov/">NIH Grants & Funding</a> site for a list of acceptable potential uses.</p>
</div>

<div data-element-id="268274" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark268274' tabindex='-1' aria-hidden='true'></a><p>See <a href="#_Section_VIII._Other">Section VIII. Other Information</a> for award authorities and regulations.</p>
</div>

<div data-element-id="268275" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark268275' tabindex='-1' aria-hidden='true'></a><p>Investigators proposing NIH-defined clinical trials may refer to the <a href="https://researchmethodsresources.nih.gov/">Research Methods Resources</a> website for information about developing statistical methods and study designs.</p>
</div>

<div data-element-id="268276" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268276' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
</div>

<div class="row" data-index="36">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268277" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268277' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>The funding instrument will be the same as the Parent Award.</p><p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p><p>Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.</p>
</div>
</div>

<div class="row" data-index="37">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268278" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268278' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
<p>Non-competing Administrative Supplements.</p>
</div>
</div>

<div class="row" data-index="38">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268279" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268279' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
</div>
<div class=" col-md-8 datacolumn">
<p>Optional: Accepting applications that either propose or do not propose clinical trial(s)</p>

<p>Administrative supplement applications may not propose changes to the overall human subjects or clinical trial designation of the award.</p>
</div>
</div>

<div class="row" data-index="39">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark268280' tabindex='-1' aria-hidden='true'></a><p><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a></p>
</div>
</div>

<div class="row" data-index="40">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268281" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268281' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.</p>
</div>
</div>

<div class="row" data-index="41">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268282" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268282' tabindex='-1' aria-hidden='true'></a>Award Budget
</div>
<div class=" col-md-8 datacolumn">
<p>Application budgets are limited to no more than the amount of the current parent award and must reflect the actual needs of the proposed project.</p><p>The funding mechanism being used to support this program, administrative supplements, can be used to provide for an increase in costs due to unforeseen circumstances. All costs must be within the current scope of the peer reviewed and approved project, and may not extend beyond the term of the current award.</p>
</div>
</div>

<div class="row" data-index="42">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="268283" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268283' tabindex='-1' aria-hidden='true'></a>Award Project Period
</div>
<div class=" col-md-8 datacolumn">
<p>The project and budget periods must be within the currently approved project period for the existing parent award. </p><p>Administrative supplements are not permitted during a no-cost extension and will be considered only in rare situations (e.g., public health emergency declaration, or natural disaster). </p>
</div>
</div>

<div data-element-id="268284" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark268284' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this Notice of Funding Opportunity (NOFO).</p>
</div>

<div data-element-id="268285" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268285' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
</div>

<div data-element-id="268286" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268286' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
</div>

<div class="heading4" tabindex="0" data-element-id="268287" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268287' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
</div>

<div data-element-id="268287" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>All organizations administering an eligible parent award may apply for a supplement under this NOFO.</p><p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized)</li></ul>
</div>

<div data-element-id="268288" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268288' tabindex='-1' aria-hidden='true'></a><p>Federal Government</p>

<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>

<div data-element-id="268289" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268289' tabindex='-1' aria-hidden='true'></a><p>Other</p>

<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
<li>Non-domestic (non-U.S.) Entities (Organizations)</li>
</ul>
</div>

<div data-element-id="268290" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268290' tabindex='-1' aria-hidden='true'></a><p>REMINDER: This funding opportunity is for supplements to existing projects. To be eligible, the parent award must be active, and the research proposed in the supplement must be accomplished within the competitive segment. The proposed supplement must be to provide for an increase in costs due to unforeseen circumstances. All additional costs must be within the scope of the peer reviewed and approved project.</p><p>IMPORTANT: The research proposed by the NIH recipient in the supplement application must be within the original scope of the NIH-supported grant project.</p>
</div>

<div data-element-id="268291" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268291' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
</div>

<div data-element-id="268292" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark268292' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organizations) <strong>are </strong>eligible to apply.</p>
</div>

<div data-element-id="268293" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark268293' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are </strong>eligible to apply.</p>
</div>

<div data-element-id="268294" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark268294' tabindex='-1' aria-hidden='true'></a><p>Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the <em>NIH Grants Policy Statement</em></a>, <strong>are </strong>allowed. </p>
</div>

<div data-element-id="268295" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268295' tabindex='-1' aria-hidden='true'></a><p>All activities with foreign institutions must align with existing parent award.</p><p>NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.</p><p>Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or <a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_1/1.2_definition_of_terms.htm">foreign components</a>, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.</p>
</div>

<div class="heading4" tabindex="0" data-element-id="268297" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268297' tabindex='-1' aria-hidden='true'></a>Required Registrations
</div>

<div data-element-id="268297" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p><strong>Applicant Organizations</strong></p>

<p>Applicant organizations must complete and maintain the following registrations as described in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registration in advance of a due date is not a valid reason for a late submission, please reference <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement 2.3.9.2 Electronically Submitted Applications </a>for additional information.</p>

<ul>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82390">System for Award Management (SAM) –</a> Applicants must complete and maintain an active registration, <strong>which requires renewal at least annually</strong>. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.

<ul style="list-style-type:circle">
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176">NATO Commercial and Government Entity (NCAGE) Code</a> – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.</li>
<li>Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.</li>
</ul>
</li>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=11123">eRA Commons</a> - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.</li>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82300">Grants.gov</a> – Applicants must have an active SAM registration in order to complete the Grants.gov registration.</li>
</ul>

<p><strong>Program Directors/Principal Investigators (PD(s)/PI(s))</strong></p>

<p>All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.</p>
</div>

<div class="heading4" tabindex="0" data-element-id="268298" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268298' tabindex='-1' aria-hidden='true'></a>Eligible Individuals (Program Director/Principal Investigator)
</div>

<div data-element-id="268298" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support. </p><p>For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>.</p><p>Individual(s) must be a PD(s)/PI(s) on an active grant or cooperative agreement, and the research proposed in the supplement must be accomplished within the competitive segment of the active award. Individuals are encouraged to work with their organizations to develop applications for support.</p><p>For supplements to parent awards that include multiple PDs/PIs, the supplement may be submitted by the recipient organization of the parent award on behalf of any or all of the PDs/PIs (in accordance with the existing leadership plan). Do not use this administrative supplement application to add, delete, or change the PDs/PIs listed on the parent award. Visit the Multiple Program Director/Principal Investigator Policy in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> for more information.</p>
</div>

<div data-element-id="268300" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268300' tabindex='-1' aria-hidden='true'></a><h4>2. Cost Sharing</h4><p>This NOFO does not require cost sharing as defined in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11126">NIH Grants Policy Statement Section 1.2 Definition of Terms</a>. </p>
</div>

<div data-element-id="268301" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268301' tabindex='-1' aria-hidden='true'></a><h4>3. Additional Information on Eligibility</h4><p><strong>Number of Applications</strong></p>
</div>

<div data-element-id="268302" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark268302' tabindex='-1' aria-hidden='true'></a><p>Applicant organizations may submit more than one application, if each is sufficiently distinct from any other administrative supplement currently under consideration by the awarding NIH Institute or Center. Administrative supplements do not count against <a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-132.html">six</a> applications allowed from individual PD/PIs.</p><p>Since applications to this NOFO will only receive administrative review by the awarding Institute or Center, and will not receive a peer review, the NIH policy on resubmissions will not apply. However, applications not accepted by the Institute or Center for review, or not funded by the Institute or Center, should not be submitted again without either responding to any written concerns or contacting the awarding Institute or Center for instructions.</p>
</div>

<div data-element-id="268304" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="ASI" data-element-type="TEXT">
<a id='_bookmark268304' tabindex='-1' aria-hidden='true'></a><a name="_Section IV. Application and Submission Information"></a><h2>Section IV. Application and Submission Information</h2>
</div>

<div data-element-id="268305" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="ASI" data-element-type="TEXT">
<a id='_bookmark268305' tabindex='-1' aria-hidden='true'></a><h4>1. Requesting an Application Package</h4><p>Applicants must prepare applications using current forms in accordance with the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>.</p><p>The application forms package specific to this opportunity must be accessed through <a href="https://grants.nih.gov/grants/how-to-apply-application-guide/prepare-to-apply-and-register/submission-options/assist.htm">ASSIST</a>, <a href="https://www.grants.gov/applicants/workspace-overview.html">Grants.gov Workspace</a> or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.</p>
</div>

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<title>PA-26-001: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

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<a id='_bookmark268243' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark268244' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark268246' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>NATIONAL INSTITUTES OF HEALTH (<a href="https://www.nih.gov/" target="_blank" rel="noreferrer">NIH</a>)
<p>National Eye Institute (<a href="https://www.nei.nih.gov/" target="_blank" rel="noreferrer">NEI</a>)
</p>
<p>National Heart, Lung, and Blood Institute (<a href="https://www.nhlbi.nih.gov/" target="_blank" rel="noreferrer">NHLBI</a>)
</p>
<p>National Human Genome Research Institute (<a href="https://www.genome.gov/" target="_blank" rel="noreferrer">NHGRI</a>)
</p>
<p>National Institute on
Aging (<a href="https://www.nia.nih.gov/" target="_blank" rel="noreferrer">NIA</a>)
</p>
<p>National Institute on Alcohol Abuse and Alcoholism (<a href="https://www.niaaa.nih.gov/" target="_blank" rel="noreferrer">NIAAA</a>)
</p>
<p>National Institute of Allergy and Infectious Diseases (<a href="https://www.niaid.nih.gov/" target="_blank" rel="noreferrer">NIAID</a>)
</p>
<p>National Institute of Arthritis and Musculoskeletal and Skin Diseases (<a href="https://www.niams.nih.gov/" target="_blank" rel="noreferrer">NIAMS</a>)
</p>
<p>National Institute of Biomedical Imaging and Bioengineering (<a href="https://www.nibib.nih.gov/" target="_blank" rel="noreferrer">NIBIB</a>)
</p>
<p>Eunice Kennedy Shriver National Institute of Child Health and Human Development (<a href="https://www.nichd.nih.gov/" target="_blank" rel="noreferrer">NICHD</a>)
</p>
<p>National Institute on Deafness and Other Communication Disorders (<a href="https://www.nidcd.nih.gov/" target="_blank" rel="noreferrer">NIDCD</a>)
</p>
<p>National Institute of Dental and Craniofacial Research (<a href="https://www.nidcr.nih.gov/" target="_blank" rel="noreferrer">NIDCR</a>)
</p>
<p>National Institute of Diabetes and Digestive and Kidney Diseases (<a href="https://www.niddk.nih.gov/" target="_blank" rel="noreferrer">NIDDK</a>)
</p>
<p>National Institute on Drug Abuse (<a href="https://www.drugabuse.gov/" target="_blank" rel="noreferrer">NIDA</a>)
</p>
<p>National Institute of Environmental Health Sciences (<a href="https://www.niehs.nih.gov/" target="_blank" rel="noreferrer">NIEHS</a>)
</p>
<p>National Institute of General Medical Sciences (<a href="https://www.nigms.nih.gov/" target="_blank" rel="noreferrer">NIGMS</a>)
</p>
<p>National Institute of Mental Health (<a href="https://www.nimh.nih.gov/index.shtml" target="_blank" rel="noreferrer">NIMH</a>)
</p>
<p>National Institute of Neurological Disorders and
Stroke (<a href="https://www.ninds.nih.gov/" target="_blank" rel="noreferrer">NINDS</a>)
</p>
<p>National Institute of Nursing Research (<a href="https://www.ninr.nih.gov/" target="_blank" rel="noreferrer">NINR</a>)
</p>
<p>National Institute on Minority Health and Health Disparities (<a href="https://www.nimhd.nih.gov/" target="_blank" rel="noreferrer">NIMHD</a>)
</p>
<p>National Library of Medicine (<a href="https://www.nlm.nih.gov/" target="_blank" rel="noreferrer">NLM</a>)
</p>
<p>Fogarty International Center (<a href="https://www.fic.nih.gov/Pages/Default.aspx" target="_blank" rel="noreferrer">FIC</a>)
</p>
<p>National Center for Complementary and Integrative Health (<a href="https://nccih.nih.gov/" target="_blank" rel="noreferrer">NCCIH</a>)
</p>
<p>National Center for Advancing Translational Sciences (<a href="https://ncats.nih.gov/" target="_blank" rel="noreferrer">NCATS</a>)
</p>
<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (<a href="https://orip.nih.gov/" target="_blank" rel="noreferrer">ORIP</a>)
</p>
<p>Office of Strategic Coordination (<a href="https://commonfund.nih.gov/" target="_blank" rel="noreferrer">Common Fund</a>)
</p>
<p>National Cancer Institute (<a href="https://www.cancer.gov/" target="_blank" rel="noreferrer">NCI</a>)
</p>
<p>Office of The Director, National Institutes of Health (<a href="https://www.nih.gov/institutes-nih/nih-office-director" target="_blank" rel="noreferrer">OD</a>)
</p>