ACS - Fanconi Cancer Foundation Discovery Boost Grant

The ACS - Fanconi Cancer Foundation Discovery Boost Grant invites innovative proposals for translational cancer research addressing the challenges faced by individuals with Fanconi anemia (FA). This grant supports high-risk, high-reward projects aimed at improving detection, prevention, or treatment of FA-related cancers. With funding of up to $135,000 per year for two years, it encourages research in early detection technologies, prevention mechanisms, and therapeutic strategies tailored to the unique sensitivities of the FA population.

About the Fanconi Cancer Foundation
FCF has funded over $32 million in research worldwide, driving advances in bone marrow transplant, gene therapy, and cancer prevention. Current initiatives include a FA data commons, global research consortia, and a repository of shared research materials. FCF fosters scientific collaboration, community empowerment, and clinical innovation to improve and extend the lives of individuals with FA.
The American Cancer Society (ACS) and the Fanconi Cancer Foundation (FCF) have partnered to invite proposals for translational cancer research projects that address the unique challenges faced by individuals with Fanconi anemia (FA). FA is a rare inherited disorder caused by mutations in genes critical for DNA repair, including BRCA1 and BRCA2.
This award will support high-risk, high-reward projects with transformative potential—innovative ideas that push the boundaries of current understanding and hold promise for meaningful clinical application. We aim to fund bold translational research that can lead to improved detection, prevention, or treatment of cancers in individuals with FA.
Areas of interest include, but are not limited to:

• Early detection technologies and biomarkers for FA-related squamous cell carcinomas

Mechanisms or interventions to prevent FA-related tumorsTherapeutic strategies tailored to the FA population’s sensitivity to DNA-damaging agentsNovel models to study FA tumorigenesis and treatment responseHigh-throughput or systems biology approaches to identify FA-specific cancer vulnerabilities
Awards are for up to $135,000 direct costs per year for up to 2 years, plus 10% indirect costs. The maximum allowable budget is $297,000 for a 2-year project period.

Eligibility

Typically, you are eligible to submit a proposal if you:

• Work at a US academic institution or eligible non-profitAre an independent investigator at any career stage with a full-time faculty appointment (or equivalent)