National Institutes of Health logo

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)

National Institutes of Health

Federal Grants for Science Research
Apply Now

Funding Amount

Up to $200,000

Deadline

June 23, 2026

76 days left

Grant Type

federal

Overview

Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)

Many valuable and widely available data sets have been generated by multiple Common Fund programs. The purpose of this NOFO is to announce the availability of funding to demonstrate and enhance the utility of selected Common Fund (https://commonfund.nih.gov/) data sets, including generating hypotheses and catalyzing discoveries. Award recipients are asked to provide feedback on the utility of the Common Fund data resources.

Details

  • Agency: National Institutes of Health
  • Department: Department of Health and Human Services
  • Opportunity #: RFA-RM-26-017
  • Total Funding: $4,000,000
  • Expected Awards: 13
  • Instrument: grant

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborati

Eligibility

Eligible Applicant Types

other_native_american_tribal_organizationsindependent_school_districtsfederally_recognized_native_american_tribal_governmentsfor_profit_organizations_other_than_small_businessespublic_and_state_institutions_of_higher_educationprivate_institutions_of_higher_educationnonprofits_non_higher_education_without_501c3city_or_township_governmentsnonprofits_non_higher_education_with_501c3county_governmentspublic_and_indian_housing_authoritiesstate_governmentsspecial_district_governmentsothersmall_businesses

How to Apply

RFA-RM-26-017-Full-Announcement.html

<!DOCTYPE html>
<html lang="en">
<head>
<meta name="viewport" content="width=device-width, initial-scale=1">
<meta http-equiv="Content-Type" content="text/html; charset=utf-8"/>
<link href='../../../images/grantsolutions/favicon.ico' rel='icon'></link>
<link rel="stylesheet" href="https://grants.nih.gov/grants/guide/pa-files/css/bootstrap.min.css"></link>
<link rel="stylesheet" href="https://grants.nih.gov/grants/guide/guide_styles/css/style.css"></link>
<script src=''></script>
<style>
a {
color: #1F6BB2 !important;
}
table#keyDatesContentTable tbody tr:last-child {
border-bottom: 2px solid #bcbcbc;
}
table#keyDatesContentTable tbody tr td:nth-child(3),
table#keyDatesContentTable tbody tr td:nth-child(6) {
border-right:2px solid #bcbcbc;
}
table#keyDatesContentTable tbody tr td:first-child {
border-left:2px solid #bcbcbc;
}

figure.table table{
width: 100%;
height: 100%;
}
.table thead>tr>th,
.table tbody>tr>th,
.table tfoot>tr>th,
.table thead>tr>td,
.table tbody>tr>td,
.table tfoot>tr>td,
figure.table table,
figure.table th,
figure.table tr,
figure.table td {
border: 1px solid rgb(0, 0, 0);
border-spacing: 0;
}

</style>
<style> .ck-indent-1{ margin-left:25px; } .ck-indent-2{ margin-left:50px; } .ck-indent-3{ margin-left:75px; } .ck-indent-4{ margin-left:100px; } .ck-indent-5{ margin-left:125px; } .ck-indent-6{ margin-left:150px; } .ck-indent-7{ margin-left:175px; } .ck-indent-8{ margin-left:200px; } .ck-indent-9{ margin-left:225px; } .ck-indent-10{ margin-left:250px; } .ck-indent-11{ margin-left:275px; } .ck-indent-12{ margin-left:300px; } .ck-indent-13{ margin-left:325px; } .ck-indent-14{ margin-left:350px; } .ck-indent-15{ margin-left:375px; } .ck-indent-16{ margin-left:400px; } .ck-indent-17{ margin-left:425px; } .ck-indent-18{ margin-left:450px; } .ck-indent-19{ margin-left:475px; } .ck-indent-20{ margin-left:500px; } </style>
<title>RFA-RM-26-017: Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)</title>

<script>
function initContent() {
if (typeof window.jQuery == 'undefined') {
return;
}

// Init headings
for (i=1; i<5; i++) {
$('h'+i).each(function(index, element) {
$(element).replaceWith('<div class="heading'+i+'">'+$(element).html()+'</div>');
});
}

// Init links so they open in new window
$('a').each(function(index, element) {
if ($(element).attr('href') && $(element).attr('href').indexOf('http') >= 0) {
$(element).attr('target','_blank');
}
});

}

</script>

</head>
<body onload="initContent()">
<div class="container">
<div class="row">
<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

<div>

<div data-element-id="261213" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261213' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
</div>

<div class="row" data-index="2">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261214" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261214' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
</div>
<div class=" col-md-8 datacolumn">
<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
</div>
</div>

<div class="row" data-index="3">
<div class="col-md-push-4 col-md-8 datacolumn">

</div>
</div>

<div class="row" data-index="4">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261216" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261216' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
</div>
<div class=" col-md-8 datacolumn">
<p>NATIONAL INSTITUTES OF HEALTH (<a href="https://www.nih.gov/" target="_blank" rel="noreferrer">NIH</a>)
</div>
</div>

<div class="row" data-index="5">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261217' tabindex='-1' aria-hidden='true'></a><p>This Notice of Funding Opportunity (NOFO) is developed as a Common Fund initiative (<a href="http://commonfund.nih.gov/">http://commonfund.nih.gov/</a>) through the Office of the NIH Director, Office of Strategic Coordination (<a href="https://dpcpsi.nih.gov/">https://dpcpsi.nih.gov/</a>). All NIH Institutes and Centers participate in Common Fund initiatives. The NOFO will be administered by the National Institute of Dental and Craniofacial Research (NIDCR), (<a href="http://www.nidcr.nih.gov/"><u>http://www.nidcr.nih.gov</u></a>) on behalf of the NIH.</p>
</div>
</div>

<div class="row" data-index="6">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261218" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261218' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
</div>
<div class=" col-md-8 datacolumn">
<span class="title">Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)</span>
</div>
</div>

<div class="row" data-index="7">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261219" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261219' tabindex='-1' aria-hidden='true'></a>Activity Code
</div>
<div class=" col-md-8 datacolumn">
<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=r03&amp;Search.x=0&amp;Search.y=0&amp;sort=ac&amp;Search_Type=Activity&amp;text_prev=">R03</a> Small Grant Program</p>
</div>
</div>

<div class="row" data-index="8">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261220" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261220' tabindex='-1' aria-hidden='true'></a>Announcement Type
</div>
<div class=" col-md-8 datacolumn">
Reissue of

<a href="https://www.grants.gov/search-results-detail/353398" target="_blank" rel="noreferrer">RFA-RM-24-006</a>



<br/>
</div>
</div>

<div class="row" data-index="9">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261221" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261221' tabindex='-1' aria-hidden='true'></a>Related Notices
</div>
<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
</div>
</div>

<div class="row" data-index="10">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261222" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261222' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
</div>
<div class=" col-md-8 datacolumn">
<span class="noticenum">RFA-RM-26-017</span>
</div>
</div>

<div class="row" data-index="11">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261223" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261223' tabindex='-1' aria-hidden='true'></a>Companion Funding Opportunity
</div>
<div class=" col-md-8 datacolumn">
None
</div>
</div>

<div class="row" data-index="12">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261224" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261224' tabindex='-1' aria-hidden='true'></a>Number of Applications
</div>
<div class=" col-md-8 datacolumn">
<p>See Section III. 3. Additional Information on Eligibility.</p>
</div>
</div>

<div class="row" data-index="13">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261225" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261225' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
</div>
<div class=" col-md-8 datacolumn">
93.310
</div>
</div>

<div class="row" data-index="14">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261226" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261226' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Purpose
</div>
<div class=" col-md-8 datacolumn">
<p>Many valuable and widely available data sets have been generated by multiple Common Fund programs. The purpose of this NOFO is to announce the availability of funding to demonstrate and enhance the utility of selected Common Fund (<a href="https://commonfund.nih.gov/">https://commonfund.nih.gov/</a>) data sets, including generating hypotheses and catalyzing discoveries. Award recipients are asked to provide feedback on the utility of the Common Fund data resources.</p>
</div>
</div>

<div class="row" data-index="16">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261228" data-element-required="true" data-element-has-value="true" data-section-code="OI" data-element-type="TEXT">
<a id='_bookmark261228' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
</div>
<div class=" col-md-8 datacolumn">
<p>The Office of Strategic Coordination (<a href="https://commonfund.nih.gov/">Common Fund</a>) supports research and other projects that will accelerate fundamental biomedical discovery and translation of that knowledge into effective prevention strategies and new treatments.</p>
</div>
</div>

<!--This variable defines that we need to start a new row. -->

<div data-element-id="261229" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261229' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
</div>

<div class="row" data-index="18">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261230" data-element-required="false" data-element-has-value="true" data-section-code="KD" data-element-type="DATE">
<a id='_bookmark261230' tabindex='-1' aria-hidden='true'></a>Posted Date
</div>
<div class=" col-md-8 datacolumn">
January 30, 2026
</div>
</div>

<div class="row" data-index="19">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261231" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261231' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
</div>
<div class=" col-md-8 datacolumn">
May 23, 2026
</div>
</div>

<!--This variable defines that we need to start a new row. -->

<div data-element-id="261233" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261233' tabindex='-1' aria-hidden='true'></a>
<table class="table table-bordered table-striped table-hover eraDataTable" id="keyDatesContentTable">
<thead>
<tr>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
</tr>
<tr>
<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">Earliest Start Date</th>
</tr>
</thead>
<tbody>
<tr>
<td>
June 23, 2026
</td>
<td>
Not Applicable
</td>
<td>
Not Applicable
</td>
<td>November 2026</td>
<td> January 2027

</td>
<td>April 2027</td>
</tr>
</tbody>
</table>
</div>

<div data-element-id="261234" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="TEXT">

</div>

<div data-element-id="261235" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261235' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization.&nbsp;</p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
</div>

<div data-element-id="261236" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="CHECKBOX">

</div>

<div data-element-id="261237" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="TEXT">

</div>

<div data-element-id="261238" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="TEXT">

</div>

<div data-element-id="261239" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="TEXT">

</div>

<div data-element-id="261240" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="KD" data-element-type="TEXT">

</div>

<div class="row" data-index="28">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261241" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261241' tabindex='-1' aria-hidden='true'></a>Due Dates for E.O. 12372
</div>
<div class=" col-md-8 datacolumn">
<p class="Normal">Not Applicable</p>
</div>
</div>

<div class="row" data-index="29">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261242" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261242' tabindex='-1' aria-hidden='true'></a>Expiration Date
</div>
<div class=" col-md-8 datacolumn">
June 24, 2026
</div>
</div>

<!--This variable defines that we need to start a new row. -->
<div class="heading4" tabindex="0" data-element-id="261243" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark261243' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
</div>

<div data-element-id="261243" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<p>It is critical that applicants follow the instructions in the Research (R) Instructions in the&nbsp;<a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>).</p>

<p>Conformance to all requirements (both in the Application Guide and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions.</p>

<p><strong>Applications that do not comply with these instructions may be delayed or not accepted for review.</strong></p>
</div>

<div data-element-id="262235" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="KD" data-element-type="TEXT">
<a id='_bookmark262235' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the&nbsp;<a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and&nbsp;<a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li><li>Use&nbsp;<a href="https://grants.gov/search-grants?oppStatuses=closed|archived|posted|forecasted&amp;fon=PA-25-301">Grants.gov</a> Workspace to prepare and submit your application and&nbsp;<a href="http://public.era.nih.gov/commons/">eRA Commons</a> to track your application.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

<div data-element-id="261245" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261245' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>

<div data-element-id="261246" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261246' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>

<div data-element-id="261247" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261247' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;"><strong>Introduction</strong></p><p>This Notice of Funding Opportunity (NOFO) aims to promote innovative research to enhance the utility and usability of selected Common Fund (CF) data sets. The submission of small research (R03) applications is encouraged from institutions and organizations proposing projects that lead to enhanced use of selected Common Fund (<a href="https://commonfund.nih.gov/">https://commonfund.nih.gov/</a>) data sets by the wider scientific community.</p><p>Small research (R03) grants provide flexibility for initiating discrete, well-defined projects that can be completed in one year and require only limited levels of funding. To be eligible for consideration through this NOFO, the proposed research plan must either: 1) <strong>substantially leverage data from at least TWO eligible Common Fund programs (see the complete list in the Objectives and Scope section),&nbsp;or&nbsp; &nbsp;2) substantially leverage data from Molecular Transducers of Physical Activity in Humans (MoTrPAC) with or without additional external study data...&nbsp;</strong>&#147;Substantial leverage&#148; is defined as the use and citation of the relevant dataset(s) in the envisioned research products of the proposed work (e.g., manuscripts, presentations, book chapters, portals, etc.)&nbsp; Data from other publicly available datasets, including Common Fund programs not listed above, can be included as needed. Up to two awards will be reserved for use of MoTrPAC data.</p><p>This initiative is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have an exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress.</p><p>This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).</p><p style="margin-left:0in;"><strong>Background</strong></p><p>The NIH Common Fund (<a href="https://commonfund.nih.gov/">https://commonfund.nih.gov/</a>) has supported many transformative research programs that generate new technologies, methods, and data. Many of these programs generate rich public data sets containing multi-dimensional molecular and phenotypic data from several organisms, including mice and humans. To maximize the impact of these data, engage a broader community of end-users for wider adoption of these data sets, and to obtain feedback from successful applicants to enhance the data resources, the Common Fund plans to support small research projects (R03) encouraging the use of Common Fund data sets. Awards are intended to enable novel and compelling biological questions to be formulated and addressed, and/or to generate cross-cutting hypotheses for future research.</p><p style="margin-left:0in;"><strong>Objectives and Scope</strong></p><p>The goals of this NOFO are to 1) promote the use of Common Fund data sets by supporting pilot studies based on analyses across two or more Common Fund data sets; 2) enhance the utility of existing Common Fund data sets by developing workflows, analytic and simulation tools which will enable simultaneous analysis of multiple Common Fund data sets; and 3) demonstrate the added-value of integrating multiple Common Fund data resources in addressing biomedical research questions.</p><p>Investigators are encouraged to utilize various approaches including, but not limited to, systems approaches, artificial intelligence (including generative)/machine learning/deep learning methods, advanced data science methods for data set integration and harmonization, and incorporating computational modeling to bring together high throughput genotype and phenotype data sets. Because information regarding the user experience could help NIH improve its data resources, the recipients will&nbsp; provide feedback on the find ability, usability, and utility of data sets and public data portals, which the awardees will offer during a virtual CFDE R03 awardee meeting and in their close-out reports.</p><p>The established Common Fund data sets listed below are well-poised for increased community use. Applicants must propose using <strong>TWO</strong> or more Common Fund program data sets from the following list, and they can propose using other data sets (including additional NIH Common Fund data sets not listed, other NIH data sets, and non-NIH data sets that are publicly available). Note: applications that use MoTrPAC study data without including other CF datasets below will be considered. Like all applications for this award, other publicly available data is allowed. Applications using MoTrPAC data with CF datasets may be submitted and will be awarded in consideration with all multi-CF applications.</p><ul><li>4D Nucleome (4DN) (<a href="https://www.4dnucleome.org/">https://www.4dnucleome.org/</a>):&nbsp; Reference nucleomics and imaging data sets, including an expanding tool set for open data processing and visualization</li><li>Acute to Chronic Pain Signatures (A2CPS) (<a href="https://a2cps.org/">https://a2cps.org/</a>): Imaging, high-throughput omics, sensory testing, and psychosocial assessment data from patients who either transition to or are resilient to chronic pain</li><li>Bridge to Artificial Intelligence (Bridge2AI) (<a href="https://bridge2ai.org/">https://bridge2ai.org/</a>): Ethically sourced, trustworthy, and well-defined flagship biomedical and behavioral datasets on salutogenesis, clinical care, functional genomics, and voice as a biomarker. This program is in its early phase, and data generation is ongoing.</li><li>Cellular Senescence Network (SenNet) (<a href="https://commonfund.nih.gov/senescence">https://commonfund.nih.gov/senescence</a>): Atlases and datasets of senescent cells and their secretomes. This program is in its early phase, and data generation is ongoing.</li><li>Extracellular RNA Communication (exRNA) (<a href="https://exrna.org/">https://exrna.org/</a>): Catalog of exRNA molecules found in human biofluids like plasma, saliva, and urine; and potential exRNA biomarkers for diseases</li><li>Gabriella First Kids First (KF) (<a href="https://kidsfirstdrc.org/">https://kidsfirstdrc.org/</a>):&nbsp; Data from whole-genome sequencing of cohorts with structural birth defects and/or susceptibility to childhood cancer, with associated phenotypic and clinical data</li><li>Genotype-Tissue Expression (GTEx) (<a href="https://www.gtexportal.org/home/">https://www.gtexportal.org/home/</a>):&nbsp; Whole genome- and RNA sequence data from multiple human tissues to study tissue-specific gene expression and regulation, including tissue samples</li><li>Glycoscience (GL) (<a href="https://glygen.org/">https://glygen.org/</a>): A data integration and dissemination project for carbohydrate and glycoconjugate related data</li><li>Human BioMolecular Atlas Program (HuBMAP) (<a href="https://hubmapconsortium.org/">https://hubmapconsortium.org/</a>): An open and global platform to map healthy cells in the human body to determine how the relationships between cells can affect the health of an individual</li><li>H3Africa (<a href="https://h3abionet.org/">https://h3abionet.org/</a>): Genomic and phenotypic research data generated by the Human Heredity and Health in Africa program, consisting of 51 projects across 30 countries. Includes population-based genomic studies of common, non-communicable disorders (e.g., heart and renal disease), as well as communicable diseases (e.g., tuberculosis).</li><li>Human Microbiome Project (HMP) (<a href="https://commonfund.nih.gov/hmp">https://commonfund.nih.gov/hmp</a>): Characterization of the microbiomes from healthy human participants at five major body sites using 16S metagenomic shotgun sequencing; as well as characterization of microbiome and human host from three cohorts of microbiome-associated conditions</li><li>Illuminating the Druggable Genome (IDG) (<a href="https://druggablegenome.net/">https://druggablegenome.net/</a>): Data on understudied druggable proteins, including mRNA and protein expression data, phenotype associations, bioactivity data, drug target interactions, disease links, and functional information</li><li>Integrated Human Microbiome Project (iHMP) (<a href="https://hmpdacc.org/ihmp/">https://hmpdacc.org/ihmp/</a>): Microbiome, epigenomic, metabolomic, and phenotypic data for three cohorts</li><li>Knockout Mouse Phenotyping Program (KOMP2) (<a href="http://www.mousephenotype.org/">http://www.mousephenotype.org/</a>): Data from broad, standardized phenotyping of a genome-wide collection of mouse knockouts</li><li>Library of Integrated Network-based Cellular Signatures (LINCS) (<a href="http://lincsproject.org/">http://lincsproject.org/</a>): Molecular signatures that describe how different types of cells respond to a variety of agents that disrupt normal cellular function</li><li>Metabolomics Workbench (<a href="https://www.metabolomicsworkbench.org/">https://www.metabolomicsworkbench.org/</a>): Metabolomics data and metadata from studies on cells, tissues, and organisms</li><li>Molecular Transducers of Physical Activity in Humans (MoTrPAC) (<a href="https://motrpac-data.org/data-access">https://motrpac-data.org/data-access</a>): Data contain assay-specific results, associated metadata, quality control reports, and animal phenotype data related to molecular transducers that underlie the effects of physical activity</li><li>Somatic Mosaicism Across Human Tissues (SmaHT) (<a href="https://commonfund.nih.gov/smaht">https://commonfund.nih.gov/smaht</a>): Data on DNA sequence variants within personal genomes in tissues from human donors. This program is in its early phase, and data generation is ongoing.</li><li>Stimulating Peripheral Activity to Relieve Conditions (SPARC) (<a href="https://sparc.science/">https://sparc.science/</a>): Maps and tools to identify and influence therapeutic targets that exist within the neural circuitry of a wide range of organs and tissues</li><li>Undiagnosed Diseases Network (UDN) (<a href="https://undiagnosed.hms.harvard.edu">https://undiagnosed.hms.harvard.edu</a>): Provides clinical, multiomics, and model organism data to provide answers for patients and families affected by these mysterious conditions</li></ul><p>This NOFO accepts different types of projects with the intent of generating preliminary and/or validation data for subsequent funding, including, but not limited to, the following:</p><ul><li>Building synthetic cohorts by combining and comparing data sets;</li><li>Incorporating CF data or CFDE Knowledge Graphs to provide grounding predictive models, using methods such as the retrieval-augmented generation (RAG) technique (CFDE&#146;s Data Distillery KG is available <a href="https://ubkg.docs.xconsortia.org/">here</a> (with CFDE-specific contexts), while others may be listed in the FAQ);</li><li>Anonymization of imaging or clinical data;</span></li><li>Incorporating CF data (e.g., raw, called, or summary) as part of a larger replication, validation, or reproducibility study;</li><li>Creating synthetic data from extant CF data to enable the use of predictive modeling or advanced modeling methods;</li><li>Leveraging existing data across humans and model organisms for novel discovery;</li><li>Developing research methods or analytic tools to support data visualization, harmonization, and integration;</li><li>Developing workflows and tools to automate data integration and interoperability;</li><li>Applying new predictive modeling/machine learning/deep learning approaches for metadata harmonization to aid in data integration;</li><li>Developing new approaches and tools for simultaneous analysis of data available on multiple platforms (e.g., data sets residing in two separate cloud platforms);</li><li>Investigating gene expression, genome topology, protein expression, and/or epigenetic patterns across several disease conditions, phases of the lifespan, or in the analysis of chronic disease;</li><li>Identifying biomarkers (metabolites, genetic variants, DNA methylation and/or histone marks, etc.) associated with various diseases and risk factors;</li><li>New approaches for integrating and analyzing single cell data;</li><li>Network analysis across genetic variation, expression profiling, and/or GWAS data to reveal pathways associated with various diseases;</li><li>Incorporating machine learning and computational approaches to imagingdata for data harmonization;</li><li>Enhancement of information in the data resources through the developing analytic tools, curating and annotating existing data, or the adding phenotypic or clinical information.</li><li>Note: CF data is well prepared for use in causal models; If experimental approaches are proposed, they should be limited to 20% of the requested budget<br><br>&nbsp;</li></ul><p>Applications are expected to utilize the existing data in the above listed Common Fund data sets. Generation of new data should be limited to testing/validation of predictions. As noted in the R&amp;R or Modular Budget section, there is a budget limit for such activities if experimental studies are proposed.</p><p>If a website or online tool is proposed for users, a sustainability plan addressing the maintenance of the tool is expected to be discussed in the submission, with plans that allow up to two additional years of maintenance/utility encouraged. Where applicable, the applicants should describe how they plan to share any tools, pipelines, or workflows used or created through open access channels (e.g., public GitHub links).</p><p>Applicants should describe the anticipated timeline, formats, and methods of providing the data generated or annotated -and other products used or created under this NOFO to the relevant Data Coordinating Center or public repository.</p><p>For applications that aim to co-analyze Common Fund data with other genomic data sets that are not yet currently accessible through an NIH-approved repository (e.g., dbGaP) or some other public controlled access database (e.g., European Genome-phenome Archive), applicants must describe the database through which the proposed data are accessible to the research community and the details of the data sets including any data use limitations based on the associated consent form and discuss the applicability of the data sets to diverse human populations.</p><p>For applications that aim to co-analyze Common Fund data with genomic data sets that are not currently accessible through an NIH-approved repository (e.g., dbGaP) or some other public controlled access database (e.g., European Genome-phenome Archive), applicants must describe their ability and willingness to submit the individual-level sequence data to an NIH-approved repository (e.g., dbGaP) and provide an associated Institutional Certification using the current NIH template (<a href="https://osp.od.nih.gov/scientific-sharing/institutional-certifications/">https://osp.od.nih.gov/-sharing/institutional-certifications/</a>). If the Institutional Certification is not available, provide a Provisional Certification and describe the anticipated data use limitations and associated modifiers separately. If submitting a Provisional Certification with the application, please note that a completed Institutional Certification may be required before award.</p><p>Frequently Asked Questions regarding this NOFO will be posted on the Common Fund Data Ecosystem Frequently Asked Questions (FAQs) (<a href="https://commonfund.nih.gov/dataecosystem/faqs">https://commonfund.nih.gov/dataecosystem/faqs</a>) website. Applicants are encouraged to review the FAQs before submitting their applications.</p>
</div>

<div data-element-id="261250" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark261250' tabindex='-1' aria-hidden='true'></a><p>See <a href="#_Section_VIII._Other">Section VIII. Other Information</a> for award authorities and regulations.</p>
</div>

<div data-element-id="261251" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261251' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
</div>

<div class="row" data-index="40">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261252" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261252' tabindex='-1' aria-hidden='true'></a>Funding Instrument
</div>
<div class=" col-md-8 datacolumn">
<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
</div>
</div>

<div class="row" data-index="41">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261253" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="LINKED_ELEMENT">
<a id='_bookmark261253' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
</div>
<div class=" col-md-8 datacolumn">
New
<br>
</div>
</div>

<div class="row" data-index="43">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261255' tabindex='-1' aria-hidden='true'></a><p>The&nbsp;<a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116">OER Glossary</a>&nbsp;and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.</p>
</div>
</div>

<div class="row" data-index="44">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261256" data-element-required="false" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261256' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
</div>
<div class=" col-md-8 datacolumn">
<p>Not Allowed: Only accepting applications that do not propose clinical trials.</p>
</div>
</div>

<div class="row" data-index="45">
<div class="col-md-push-4 col-md-8 datacolumn">
<a id='_bookmark261257' tabindex='-1' aria-hidden='true'></a><p><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a></p>
</div>
</div>

<div class="row" data-index="46">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261258" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261258' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
</div>
<div class=" col-md-8 datacolumn">
<p>The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.</p><p>The NIH Common Fund intends to commit approximately $4,000,000 in FY 2026, contingent upon receiving scientifically meritorious applications and having funds available. 10-13 awards are anticipated from this solicitation.</p>
</div>
</div>

<div class="row" data-index="47">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261259" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261259' tabindex='-1' aria-hidden='true'></a>Award Budget
</div>
<div class=" col-md-8 datacolumn">
<p style="margin-left:0in;">Application budgets are limited to $200,000 in direct costs (excluding subcontract F&amp;A) for one year and need to reflect the actual needs of the proposed project.</p>
</div>
</div>

<div class="row" data-index="48">
<div class="col-md-4 datalabel" tabindex="0" data-element-id="261260" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261260' tabindex='-1' aria-hidden='true'></a>Award Project Period
</div>
<div class=" col-md-8 datacolumn">
<p>The maximum project period for an application submitted under this NOFO is one year.</p>
</div>
</div>

<!--This variable defines that we need to start a new row. -->

<div data-element-id="261261" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="AI" data-element-type="TEXT">
<a id='_bookmark261261' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
</div>

<div data-element-id="261262" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261262' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
</div>

<div data-element-id="261263" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261263' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
</div>

<div class="heading4" tabindex="0" data-element-id="261264" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261264' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
</div>

<div data-element-id="261264" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li><li>Indian/Native American Tribal Governments (Federally Recognized)</li><li>Indian/Native American Tribal Governments (Other than Federally Recognized).</li></ul>
</div>

<div data-element-id="261265" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261265' tabindex='-1' aria-hidden='true'></a><p>Federal Governments</p>

<ul>
<li>Eligible Agencies of the Federal Government</li>
<li>U.S. Territory or Possession</li>
</ul>
</div>

<div data-element-id="261266" data-element-has-label="false" data-element-required="false" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261266' tabindex='-1' aria-hidden='true'></a><p>Other</p>

<ul>
<li>Independent School Districts</li>
<li>Public Housing Authorities/Indian Housing Authorities</li>
<li>Native American Tribal Organizations (other than Federally recognized tribal governments)</li>
<li>Faith-based or Community-based Organizations</li>
<li>Regional Organizations</li>
</ul>
</div>

<div data-element-id="261267" data-element-has-label="false" data-element-required="false" data-element-has-value="false" data-section-code="EI" data-element-type="TEXT">

</div>

<div data-element-id="261268" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261268' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
</div>

<div data-element-id="261269" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261269' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organizations) <strong>are not</strong> eligible to apply.</p>
</div>

<div data-element-id="261270" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261270' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
</div>

<div data-element-id="261271" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="RADIO_BUTTON">
<a id='_bookmark261271' tabindex='-1' aria-hidden='true'></a><p class="Normal">Foreign components, as&#160;<a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the NIH Grants Policy Statement</a>, <b>are </b>allowed.</p>
</div>

<div data-element-id="262147" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark262147' tabindex='-1' aria-hidden='true'></a><p>NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations.&nbsp;This new requirement was effective, May 1, 2025.</p><p>Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or&nbsp;<a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_1/1.2_definition_of_terms.htm">foreign components</a>, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.</p>
</div>

<div class="heading4" tabindex="0" data-element-id="261272" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<a id='_bookmark261272' tabindex='-1' aria-hidden='true'></a>Required Registrations
</div>

<div data-element-id="261272" data-element-has-label="true" data-element-required="true" data-element-has-value="true" data-section-code="EI" data-element-type="TEXT">
<p><strong>Applicant Organizations</strong></p>

<p>Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference the&nbsp;<a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications</a>&nbsp;for additional information.</p>

<ul>
<li><a href="https://grants.nih.go

Apply with Grantable Learn more

Focus Areas & Funding Uses

Fields of Work

science-research

Categories

Browse similar grants by category

Grants for Science Research

Related Grants

Similar grants from this funder and related organizations

Federal

Findable Accessible Interoperable Reusable Open Science

U.S. National Science Foundation

Amount

$6,000,000 total

Deadline

Closed

Federal

Fiscal Year 2026 Scientific Infrastructure Support for Consolidated Innovative Nuclear Research

Idaho Field Office

Amount

$0 - $1,500,000

Deadline

April 9, 2026

Federal

Pilot Program to Increase Research Capacity at Historically Black Colleges and Universities and Other Minority-Serving Institutions

Dept of the Army -- Materiel Command

Amount

$1,500,000 - $10,000,000

Deadline

April 10, 2026

Federal

ROSES 2025: B.4 Space Weather Science Application Research-to-Operations-to-Research

NASA Headquarters

Amount

Varies

Deadline

April 10, 2026

Federal

Advanced Rehabilitation Research Training (ARRT) Program - Community Living and Participation

Administration for Community Living

Amount

$245,000 - $250,000

Deadline

April 13, 2026

Federal

FY 2026 Implementation of the U.S. Integrated Ocean Observing System (IOOS)

DOC NOAA - ERA Production

Amount

$2,000,000 - $5,000,000

Deadline

April 13, 2026

Ready to apply for Pilot Projects Enhancing Utility and Usage of Common Fund Data Sets (R03 Clinical Trial Not Allowed)?

Grantable helps you assess fit, draft narratives, and track deadlines — so you can submit stronger applications, faster.

Apply with Grantable Learn more