Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)
National Institutes of Health
Funding Amount
$878,000 total
Deadline
May 1, 2026
22 days left
Grant Type
federal
Overview
Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)
The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The ICSC is expected to provide informatics and coordinating services to the MMRRC consortium and biomedical researchers. Important functions of the ICSC are improvement, development, and maintenance of the Consortium"s in-house data management systems in a format that may facilitate their integration with other animal and non-animal resource databases and community standards for information accessibility and interoperability. Additional services include maintenance and further development of a public website portal and Customer Service Center; operation of the order processing system; review and processing of applications from donating investigators; facilitation of interactions with biomedical investigators, informatics services, database activities, and the archive of MMRRC documents and files; coordination of requests to donate mouse strains to the MMRRCs and to order mouse strains from the MMRRCs; oversight of marketing efforts; and completion of monthly and yearly metrics reports. Moreover, the ICSC will host and actively participate in the monthly teleconference, annual consortium meeting, and compose reports and summaries from these forums as requested by MMRRC consortium members or NIH staff. Of special interest of the announcement is a requirement of the Center"s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed activities should include collection and analysis of the comparative information on the use of NAMs that enhance the predictive power of human disease models and support their integration with traditional models.
Details
- Agency: National Institutes of Health
- Department: Department of Health and Human Services
- Opportunity #: RFA-OD-25-012
- Total Funding: $878,000
- Expected Awards: 1
- Instrument: grant
Eligibility
Refer to Section III. Eligibility Information for additional information on eligibility. Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Eligibility
Eligible Applicant Types
How to Apply
RFA-OD-25-012-Revised-Full-Announcement.html
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<title>RFA-OD-25-012: Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)</title>
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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>
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<a id='_bookmark259587' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark259588' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark259590' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (<a href="https://orip.nih.gov/" target="_blank" rel="noreferrer">ORIP</a>)
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<a id='_bookmark259592' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Informatics, Coordination and Service Center for the Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)</span>
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<a id='_bookmark259593' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=U42&Search.x=0&Search.y=0&Search_Type=Activity">U42</a> Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements</p>
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<a id='_bookmark259594' tabindex='-1' aria-hidden='true'></a>Announcement Type
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Reissue of
<a href="https://grants.nih.gov/grants/guide/rfa-files/RFA-OD-20-012.html" target="_blank" rel="noreferrer">RFA-OD-20-012</a>
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<a id='_bookmark259595' tabindex='-1' aria-hidden='true'></a>Related Notices
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<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark259596' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">RFA-OD-25-012</span>
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<a id='_bookmark259597' tabindex='-1' aria-hidden='true'></a>Companion Notice of Funding Opportunity
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None
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<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.</p>
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<a id='_bookmark259599' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
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93.351
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<a id='_bookmark259600' tabindex='-1' aria-hidden='true'></a>Notice of Funding Opportunity Purpose
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<p style="margin-left:9.9pt;">The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The ICSC is expected to provide informatics and coordinating services to the MMRRC consortium and biomedical researchers. Important functions of the ICSC are improvement, development, and maintenance of the Consortium’s in-house data management systems in a format that may facilitate their integration with other animal and non-animal resource databases and community standards for information accessibility and interoperability. Additional services include maintenance and further development of a public website portal and Customer Service Center; operation of the order processing system; review and processing of applications from donating investigators; facilitation of interactions with biomedical investigators, informatics services, database activities, and the archive of MMRRC documents and files; coordination of requests to donate mouse strains to the MMRRCs and to order mouse strains from the MMRRCs; oversight of marketing efforts; and completion of monthly and yearly metrics reports. Moreover, the ICSC will host and actively participate in the monthly teleconference, annual consortium meeting, and compose reports and summaries from these forums as requested by MMRRC consortium members or NIH staff. Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. Proposed activities should include collection and analysis of the comparative information on the use of NAMs that enhance the predictive power of human disease models and support their integration with traditional models.</p>
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<a id='_bookmark259602' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<div class=" col-md-8 datacolumn">
<p style="margin-left:9.9pt;">The Office of Research Infrastructure Programs (ORIP) is a program office in the Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI) dedicated to supporting research infrastructure and related research resource programs. ORIP consists of the Division of Comparative Medicine (DCM) and the Division of Construction and Instruments (DCI).</p>
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<a id='_bookmark259603' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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December 04, 2025
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<a id='_bookmark259605' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
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December 12, 2025
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<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Application Due Dates</th>
<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
<th scope="col" style="width:16.66%" class="text-center">Scientific Merit Review</th>
<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
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January 12, 2026
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January 12, 2026
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<td>
Not Applicable
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<td>July 2026</td>
<td> August 2026
</td>
<td>December 2026</td>
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May 01, 2026
</td>
<td>
May 01, 2026
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<td>
Not Applicable
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<td>November 2026</td>
<td> January 2027
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<td>April 2027</td>
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<a id='_bookmark259609' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>
<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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<a id='_bookmark259615' tabindex='-1' aria-hidden='true'></a>Expiration Date
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May 02, 2026
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<p>Not Applicable</p>
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<p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. <b>Applications that do not comply with these instructions may be delayed or not accepted for review.</b></p>
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<a id='_bookmark262226' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li></ol>
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<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>
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<a id='_bookmark259619' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
</div>
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<a id='_bookmark259620' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
</div>
<div data-element-id="259621" data-element-has-label="false" data-element-required="true" data-element-has-value="true" data-section-code="FOD" data-element-type="TEXT">
<a id='_bookmark259621' tabindex='-1' aria-hidden='true'></a><p style="margin-left:6.55pt;">This Notice of Funding Opportunity (NOFO) announces an open competition to support the Informatics, Coordination and Service Center (ICSC) unit of the Mutant Mouse Resource and Research Centers (MMRRC) consortium. The overarching purpose of the research funded by the ORIP is to support infrastructure and resources for innovative biomedical research by creating models for human diseases using animals and cultured cells, managing the infrastructure required to maintain, distribute, and utilize these models, and conducting comparative analyses with relevant NAMs resources. The ICSC is currently funded as a cooperative agreement under the U42 grant mechanism. The ICSC supports the MMRRC consortium in its mission to provide mutant mice, sperm, embryos, and embryonic stem (ES) cell lines to qualified biomedical researchers at research centers, academic institutions, for-profit organizations, the NIH, and other federal agencies conducting research across multiple biomedical fields. The MMRRC consortium operates as a collaborative effort, with the role of the ICSC being to coordinate informatics and customer service activities in accordance with operational policies guidelines established by the Coordinating Committee and written Standard Operating Procedures. Currently, the MMRRC consortium consists of four regional distribution Centers (termed the MMRRCs) and an ICSC. This NOFO is intended to provide financial support exclusively to the ICSC.</p><p style="margin-left:6.55pt;">The ICSC is expected to provide informatics and coordinating services to the MMRRCs and biomedical researchers to catalyze the rate of research progress across different biomedical fields. The ICSC should accept submission of relevant data from the community and generate its own data to store, organize, validate, archive, preserve, and distribute information in compliance with the FAIR (Findable, Accessible, Interoperable, and Reusable) Data Principles. Additionally, improving access to the ICSC’s databases and developing metrics to evaluate the usage, utility, and impact of repository activities will improve the ability of the Consortium to meet the needs of the biomedical research community. The ICSC’s services should include maintaining and further developing of a public website portal and Customer Service Center; operating the order processing system; reviewing and processing applications from donating investigators; facilitating interactions with biomedical investigators, overseeing informatics services, database activities, and archiving</span> of MMRRC documents and files; coordinating requests to donate and order mouse strains, managing marketing efforts; and compiling monthly and annual metrics reports. Moreover, the ICSC will host and actively participate in the monthly teleconference, annual consortium meeting, and will compose reports and summaries from these forums. The Center should develop an active program for monitoring and collecting information on the impact of the MMRRC consortium’s ongoing activities on biomedical research. Such information should also be included in their progress reports to the NIH.</p><p style="margin-left:6.55pt;">Of special interest of the announcement is a requirement of the Center’s close coordination with efforts to develop new approach methodologies (NAMs) that complement traditional animal-based research. These include cell culture, organoids, computational models, and microphysiological systems. NAMs enable research to be done more quickly, by more researchers, at a more affordable cost. Importantly, these advances are opening doors to complementary and more effective non-animal-based approaches for a variety of applications. The development of these NAMs holds tremendous promise for increasing the tools available to achieve the NIH mission and potentially reduce and refine the future use of animals in some areas of research in the future. It is important that the community fully understand the strengths and limitations of mouse models, as well as areas of opportunity given the current state of science, that in turn will improve selection, design, and relevance of all human disease models.</p><p style="margin-left:6.55pt;">The PD/PI of ICSC is also required to develop a high risk, high return, research pilot that complements the goals and needs of the MMRRC consortium in informatics services (the Applied Research Project). Examples of Applied Research Projects include, but are not limited to developing new metrics to measure the impact of the MMRRC consortium’s activities on biomedical research, computational approaches to assess the needs of specific mouse models to support innovative and fast developing biomedical fields as well as to assist investigators to search repository content for human disease associations, comparative data searches to increase applicability of NAMs and promote integration of the most predictive human disease models, and new marketing methods based upon evaluation of researcher interest via machine learning approaches. The Applied Research Project may comprise no more than 10 percent of the direct costs of the proposal.</p><h4>Additional Information</h4><p style="margin-left:6.55pt;">The U42 application is a multi-component application that includes an Overall Component that is the aggregate of the major "Coordination Section", Informatics Section, Customer Service and Public Relation Section Components and the minor "Applied Research Project" Component. Each of these Components is described in Section IV.2. Typically, one or more of the PDs/PIs of the Overall application also serves as a Section Head and can serve as the Lead of the Applied Research Project.</p><p style="margin-left:6.55pt;">The ICSC is expected to follow the advice of the existing MMRRC’s consortium External Advisory Board (EAB) of experts as directed by the NIH on the MMRRC consortium’s long-term sustainability and relevance to biomedical research. The EAB should provide recommendations to the PD/PI on how to enhance the capacity and quality of service provided by the ICSC, should evaluate the processes by which the ICSC engages biomedical researchers and encourages submission of new mouse strains and related materials, and should recommend which new approaches should be employed for steadily increasing new accepted materials for archiving and future distribution. Tele- or videoconferencing is encouraged to decrease costs unless the budgeted expense of face-to-face meetings is justified in the application. The ICSC also may have Internal Advisory Boards consisting of the members of its own institution.</p><p style="margin-left:6.55pt;">The MMRRCs will have an annual consortium meeting to present Center updates and research progress; to articulate new opportunities for collaboration; to evolve long-term program goals/strategies; to plan and strategize responses to the MMRRC’s EABs and user feedback; and to provide a venue for engagement with external advisors, NIH program officials, MMRRC users and other leaders of the scientific community. Each MMRRC must include a budget for attendance to each of the annual consortium meetings for their PD/PIs and key personnel.</p>
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<a id='_bookmark259624' tabindex='-1' aria-hidden='true'></a><p>See <a href="#">Section VIII. Other Information</a> for award authorities and regulations.</p>
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<a id='_bookmark259625' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
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<a id='_bookmark259626' tabindex='-1' aria-hidden='true'></a>Funding Instrument
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<p>Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.</p>
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<a id='_bookmark259627' tabindex='-1' aria-hidden='true'></a> Application Types Allowed
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New
<br>
Renewal
<br>
Resubmission
<br>
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<a id='_bookmark259629' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116"><font color="#0000ff">OER Glossary</font></a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provides details on these application types. Only those application types listed here are allowed for this NOFO.</p>
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<a id='_bookmark259630' tabindex='-1' aria-hidden='true'></a>Clinical Trial?
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<p>Not Allowed: Only accepting applications that do not propose clinical trials.</p>
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<a id='_bookmark259631' tabindex='-1' aria-hidden='true'></a><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a>
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<a id='_bookmark259632' tabindex='-1' aria-hidden='true'></a>Funds Available and Anticipated Number of Awards
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<p>One award will be made contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. </p>
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<a id='_bookmark259633' tabindex='-1' aria-hidden='true'></a>Award Budget
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<p style="margin-left:9.9pt;">The application budget should be no more than $650,000 in direct costs per year.</p>
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<a id='_bookmark259634' tabindex='-1' aria-hidden='true'></a>Award Project Period
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<p style="margin-left:0in;">The total project period may not exceed four years.</p>
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<a id='_bookmark259635' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
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<a id='_bookmark259636' tabindex='-1' aria-hidden='true'></a><a name="_Section III. Eligibility Information"></a><h2>Section III. Eligibility Information</h2>
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<a id='_bookmark259637' tabindex='-1' aria-hidden='true'></a><h4>1. Eligible Applicants</p>
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<a id='_bookmark259638' tabindex='-1' aria-hidden='true'></a>Eligible Organizations
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<p>Higher Education Institutions - Includes all types</p><ul><li>Public/State Controlled Institutions of Higher Education</li><li>Private Institutions of Higher Education</li></ul><p>Nonprofits Other Than Institutions of Higher Education</p><ul><li>Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li><li>Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)</li></ul><p>For-Profit Organizations</p><ul><li>Small Businesses</li><li>For-Profit Organizations (Other than Small Businesses)</li></ul><p>Local Governments</p><ul><li>State Governments</li><li>County Governments</li><li>City or Township Governments</li><li>Special District Governments</li></ul>
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<a id='_bookmark259642' tabindex='-1' aria-hidden='true'></a><h4>Foreign Organizations/International Collaborations</h4>
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<a id='_bookmark259643' tabindex='-1' aria-hidden='true'></a><p class="Normal">Non-domestic (non-U.S.) Entities (Foreign Organization) <strong>are not</strong> eligible to apply.</p>
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<a id='_bookmark259644' tabindex='-1' aria-hidden='true'></a><p>Non-domestic (non-U.S.) components of U.S. Organizations <strong>are not</strong> eligible to apply.</p>
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<a id='_bookmark259645' tabindex='-1' aria-hidden='true'></a><p class="Normal">Foreign components, as <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11118">defined in the NIH Grants Policy Statement</a>, <strong>are not</strong> allowed. </p>
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<a id='_bookmark259646' tabindex='-1' aria-hidden='true'></a>Required Registrations
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<p><strong>Applicant organizations</strong></p>
<p>Applicant organizations must complete and maintain the following registrations as described in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply- Application Guide</a> to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications</a> for additional information.</p>
<ul>
<li><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82390">System for Award Management (SAM)</a> – Applicants must complete and maintain an active registration, <b>which requires renewal at least annually</b>. The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
<ul style="list-style-type:circle">
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11176">NATO Commercial and Government Entity (NCAGE) Code</a> – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.</li>
<li>Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.</li>
</ul>
</li>
<li><a href="https://era.nih.gov/">eRA Commons</a> - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.</li>
<li><a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82300">Grants.gov</a> – Applicants must have an active SAM registration in order to complete the Grants.gov registration.</li>
</ul>
<p><strong>Program Directors/Principal Investigators (PD(s)/PI(s))</strong></p>
<p>All PD(s)/PI(s) must have an eRA Commons account. PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.</p>
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<a id='_bookmark259647' tabindex='-1' aria-hidden='true'></a>Eligible Individuals (Program Director/Principal Investigator)
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<p>Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. </p><p>For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>.</p>
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<a id='_bookmark259649' tabindex='-1' aria-hidden='true'></a><h4>2. Cost Sharing</h4><p>This NOFO does not require cost sharing as defined in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11126">NIH Grants Policy Statement</a><a href="https://grants.nih.gov/grants/policy/nihgps/HTML5/section_1/1.2_definition_of_terms.htm"> Section 1.2- Definitions of Terms.</a></p>
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<a id='_bookmark259650' tabindex='-1' aria-hidden='true'></a><h4>3. Additional Information on Eligibility</h4><p>Number of Applications</p>
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<a id='_bookmark259651' tabindex='-1' aria-hidden='true'></a><p>Applicant organizations may submit more than one application, provided that each application is scientifically distinct.</p>
<p>The NIH will not accept duplicate or highly overlapping applications under review at the same time per <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82415">NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application</a>. This means that the NIH will not accept:</p>
<ul>
<li>A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.</li>
<li>A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.</li>
<li>An application that has substantial overlap with another application pending appeal of initial peer review (see <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=82423">NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications</a>).</li>
</ul>
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<a id='_bookmark259653' tabindex='-1' aria-hidden='true'></a><a name="_Section IV. Application and Submission Information"></a><h2>Section IV. Application and Submission Information</h2>
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<a id='_bookmark259654' tabindex='-1' aria-hidden='true'></a><h4>1. Requesting an Application Package</h4><p>The application forms package specific to this opportunity must be accessed through ASSIST or an institutional system-to-system solution. A button to apply using ASSIST is available in Part 1 of this NOFO. See the administrative office for instructions if planning to use an institutional system-to-system solution.</p>
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<a id='_bookmark259655' tabindex='-1' aria-hidden='true'></a><h4>2. Content and Form of Application Submission</h4><p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed in this notice of funding opportunity to do otherwise (in this NOFO, in a <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">policy notice</a>, or other notice from <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11164">NIH Guide for Grants and Contracts</a>) and where instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> are directly related to the Grants.gov downloadable forms currently used with most NIH opportunities. Conformance to the requirements in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.</p>
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<a id='_bookmark259657' tabindex='-1' aria-hidden='true'></a><h4>
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