i2 Innovation Initiative Grant
Funding Amount
Not stated
Deadline
Deadline not published
Grant Type
Foundation
Can we apply?
Check your organization against each line. Taken from the listing; confirm with the funder's guidelines.
Eligible organizations
- Government entities are eligible to apply so long as the solution is designed for positive social impact in San Diego and/or Imperial counties
Required status
- 501(c)(3) tax-exempt status
- Tax-exempt status
Other requirements
- _You can learn more about this opportunity by visiting the funder's [website](https://alliancehf.org/2025-i2-challenge-grant/)._
Not eligible / not funded
- Not eligible: The following organizations are not eligible to be an applicant for the 2025 i2 Challenge Grant even if they are a Section 501(c)(3) organization or a state college or university:
- Not eligible: Mature organizations that are seeking general operating funds
- Not eligible: Organizations without a specific focus on a vulnerable or historically marginalized/under-resourced populations
- Not eligible: Organizations that seek to profit from historically marginalized/under-resourced populations
- Not eligible: Organizations without an operating focus in San Diego
- Not eligible: Organizations formed under the laws of a country other than the United States
- Not eligible: Past i2 grantees
- Not eligible: Organizations that are developing pharmaceuticals, nutraceuticals, health food, fitness service, or medical devices requiring FDA approval unless the technology is part of an evidenced-based or novel innovation that is a well-supported approach to one of the eligibility criteria below
- Not eligible: Organizations that require more than 15% of grant funds to be allocated to indirect overhead costs
- Not eligible: Individuals are not eligible to apply
Overview
Alliance Healthcare Foundation
Society, structural systems, community, neighborhood, and family are collectively responsible for creating an environment of health and wellness. Wellness is personal and not the same for everyone.
Alliance Healthcare Foundation (AHF) works to advance health and wellness for people who face significant barriers to better health. We do this in San Diego & Imperial counties through collaborative funding, convening and advocacy.
i2 Innovation Initiative
With our Innovation Initiative (i2), also referred to as “venture philanthropy,” Alliance Healthcare Foundation (AHF) seeks promising innovation to transform the current health paradigm of high cost and poor outcomes to improve quality, increase capacity, and reduce costs for the most systemically marginalized and under-resourced populations in San Diego and/or Imperial counties.
AHF seeks market-based and/or transformational systems-change solutions with the potential to improve access, quality, and health outcomes for low-income residents in San Diego.
Examples of Closing Disparities Gaps (not exhaustive):
- Chronic condition prevention and/or management (diabetes, obesity, cardiovascular)
- Access to health and wellness for those without broadband connectivity, transportation, health literacy, language fluency
- Opportunity for wealth building at lowest income levels
- Access to mental and behavioral health care for the under- and uninsured
Funding
To assist applicants with completing their Journey, AHF will be providing grant funding in the last two phases of the Journey as follows:
- Phase 2 (up to 10 applicants) – $5,000 per applicant to support the applicant’s Phase 2 validation process
- Phase 3 (up to 5 finalists) – $20,000 per applicant to support the applicant’s Phase 3 building process
Eligibility
_You can learn more about this opportunity by visiting the funder's website._
- The lead applicant must have a U.S. federal tax ID and be a 501(c)(3) nonprofit organization.
- Applicants must have a U.S. federal tax ID, be tax-exempt under IRS 501(c)(3), and the solution must be piloted and/or delivered for positive social impact in San Diego and/or Imperial counties.
- Section 501(c)(3) organizations and state colleges and universities may collaborate with social enterprises, provided that the applicant itself is a 501(c)(3) nonprofit organization or a state college or university.
- Faith-based organizations that have a tax-exempt status under IRS 501(c)(3) are considered eligible to apply.
- Public colleges and universities that are classified as tax-exempt, public charities may apply.
- Government entities are eligible to apply so long as the solution is designed for positive social impact in San Diego and/or Imperial counties.
Ineligibility
The following organizations are not eligible to be an applicant for the 2025 i2 Challenge Grant even if they are a Section 501(c)(3) organization or a state college or university:
- Mature organizations that are seeking general operating funds.
- Organizations without a specific focus on a vulnerable or historically marginalized/under-resourced populations.
- Organizations that seek to profit from historically marginalized/under-resourced populations.
- Organizations without an operating focus in San Diego.
- Organizations formed under the laws of a country other than the United States.
- Past i2 grantees.
- Organizations that are developing pharmaceuticals, nutraceuticals, health food, fitness service, or medical devices requiring FDA approval unless the technology is part of an evidenced-based or novel innovation that is a well-supported approach to one of the eligibility criteria below.
- Organizations that require more than 15% of grant funds to be allocated to indirect overhead costs.
- Individuals are not eligible to apply.
What Alliance Healthcare Foundation actually gave
Source: IRS Form 990-PF, 2025
- Grants in 2025
- 86
- Total given
- $9.43M
- Median grant
- $25K
- Range
- $400–$7.5M
- By dollars: California >99%, New York <1%. Top recipient cities: San Diego, CA; National City, CA; Chula Vista, CA.
- 0% of grants with a stated purpose were for general or operating support.
- 34% of recipients were new grantees, not repeat recipients.
Example grants
Imperial Valley Wellness Fund · Imperial, CA
Strategic grant - imperial valley wellnes fund endowment transfer
$7.5M
Urban Restoration Counseling Center · San Diego, CA
2022 i2 milestone grant tranche #4 (final)
$170K
PROMISES2KIDS Foundation · San Diego, CA
Strategic grant - economic mobility & security
$105K
CASA Familiar · San Ysidro, CA
Capacity building grant
$75K
Catalyst of San Diego & Imperial Counties · San Diego, CA
Capacity building grant
$75K
Focus Areas & Funding Uses
Fields of Work
- Healthcare
- Health disparities
Categories
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