Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

Q: How much funding does Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional) provide?

Funding amounts vary. Check the grant details for specifics.

Q: When is the deadline for Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)?

The deadline is September 25, 2028.

Overview

This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; and 2) Clinical Cancer Centers, which are primarily focused on basic laboratory; clinical; and prevention, cancer control, and population-based research; or some combination of these areas, and 3) Basic Cancer Centers, which focus on basic laboratory research. The purpose of all types of NCI-Designated Cancer Centers is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. Cancer Centers supported through this NOFO are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy; to contribute significantly to the development of Shared Resources that support research; to collaborate and coordinate their research efforts with other NCI-funded programs and investigators; and to disseminate research findings for the benefit of the community.

Details

Agency: National Institutes of Health
Department: Department of Health and Human Services
Opportunity #: PAR-25-444
Instrument: grant

Eligibility

Specific to this NOFO:For New (Type 1) applications, an applicant institution must have a funding base of $10,000,000 (Clinical Cancer Centers) or $6,000,000 (Basic Cancer Centers) in annual direct costs of NIH funding that is cancer-focused, as defined by the Research Condition and Disease Categorization (RCDC) system. Please contact the NCI Office of Cancer Centers (https://cancercenters.cancer.gov/) for assistance in determining the RCDC funding base.For Renewal (Type 2) applications, an applicant institution must have a funding base of at least $10,000,000 in annual direct costs of peer-reviewed, cancer-related funding. If the Cancer Center is an approved consortium of institutions, the funding base of the Center will be the sum of the funding bases of all participating institutions. However, funding (and other data) awarded to consortium partners may be included only if the partner has been previously evaluated in CCSG peer-review and approved by NCI.Example of NCI peer-reviewed m

Eligibility

Eligible Applicant Types

federally_recognized_native_american_tribal_governmentsfor_profit_organizations_other_than_small_businessesothercounty_governmentsother_native_american_tribal_organizationsspecial_district_governmentsnonprofits_non_higher_education_with_501c3small_businessespublic_and_state_institutions_of_higher_educationindependent_school_districtsstate_governmentscity_or_township_governmentsnonprofits_non_higher_education_without_501c3private_institutions_of_higher_education

How to Apply

PAR-25-444-Full-Announcement.html

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<title>PAR-25-444: Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

<div>

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<a id='_bookmark259587' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<a id='_bookmark259588' tabindex='-1' aria-hidden='true'></a>Participating Organization(s)
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark259590' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>National Cancer Institute (<a href="https://www.cancer.gov/" target="_blank" rel="noreferrer">NCI</a>)
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<a id='_bookmark259592' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)</span>
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<a id='_bookmark259593' tabindex='-1' aria-hidden='true'></a>Activity Code
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=p30&Search.x=0&Search.y=0&Search_Type=Activity">P30</a> Center Core Grants</p>
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<a id='_bookmark259594' tabindex='-1' aria-hidden='true'></a>Announcement Type
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Reissue of

<a href="https://grants.nih.gov/grants/guide/rfa-files/PAR-21-321.html" target="_blank" rel="noreferrer">PAR-21-321</a>

<br/>
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<a id='_bookmark259595' tabindex='-1' aria-hidden='true'></a>Related Notices
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<div class=" col-md-8 datacolumn">
<ul><li>Check for any recent <a href="https://grants.nih.gov/grants/guide/url_redirect.php?id=11163">Notices of NIH Policy Changes</a> that may impact application requirements.</li></ul>
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<a id='_bookmark259596' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Number (FON)
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<span class="noticenum">PAR-25-444</span>
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<a id='_bookmark259597' tabindex='-1' aria-hidden='true'></a>Companion Notice of Funding Opportunity
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None
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<a id='_bookmark259598' tabindex='-1' aria-hidden='true'></a>Number of Applications
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<p>See <a href="#_3._Additional_Information">Section III. 3. Additional Information on Eligibility</a>.</p>
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<a id='_bookmark259599' tabindex='-1' aria-hidden='true'></a>Assistance Listing Number(s)
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93.397
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<a id='_bookmark259600' tabindex='-1' aria-hidden='true'></a>Notice of Funding Opportunity Purpose
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<p>This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; 2) Clinical Cancer Centers, which are primarily focused on basic laboratory; clinical; and prevention, cancer control, and population-based research; or some combination of these areas; and 3) Basic Cancer Centers, which focus on basic laboratory research. The purpose of all types of NCI-Designated Cancer Centers is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. Cancer Centers supported through this NOFO are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy; to contribute significantly to the development of Shared Resources that support research; to collaborate and coordinate their research efforts with other NCI-funded programs and investigators; and to disseminate research findings for the benefit of the community.</p>
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<a id='_bookmark259602' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Goal(s)
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<p>The goal of this NOFO is to provide an organizational focus and stimulus for the highest quality cancer research that effectively promotes interdisciplinary cancer research aimed toward the ultimate goal of reducing cancer incidence, mortality and morbidity. The Cancer Center Support Grant (CCSG) provides the resources and infrastructure to facilitate the coordination of interdisciplinary programs across a broad spectrum of research from basic laboratory research to clinical investigation to population science. The CCSG supports salaries for scientific leadership of the Center, shared resources for funded center investigators, certain administrative costs, planning and evaluation, and developmental funds for new recruitments and feasibility studies.</p>
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<a id='_bookmark259603' tabindex='-1' aria-hidden='true'></a><a name="_Key Dates"></a><h2>Key Dates</h2>
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<a id='_bookmark259605' tabindex='-1' aria-hidden='true'></a>Open Date (Earliest Submission Date)
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December 01, 2025
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The following table includes NIH <a href="https://grants.nih.gov/grants/how-to-apply-application-guide/due-dates-and-submission-policies/due-dates.htm" target="_blank" rel="noreferrer">standard due dates</a> marked with an asterisk.
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<th scope="col" colspan="3" style="border:2px solid #bcbcbc;" class="text-center">Review and Award Cycles</th>
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<th scope="col" style="width:16.66%;border-left:2px solid #bcbcbc;" class="text-center">New</th>
<th scope="col" style="width:16.66%" class="text-center">Renewal / Resubmission / Revision (as allowed)</th>
<th scope="col" style="width:16.66%;border-right:2px solid #bcbcbc;" class="text-center">AIDS - New/Renewal/Resubmission/Revision, as allowed</th>
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<th scope="col" style="width:16.66%" class="text-center">Advisory Council Review</th>
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<td>
January 25, 2026 *
</td>
<td>
January 25, 2026 *
</td>
<td>
Not Applicable
</td>
<td>July 2026</td>
<td> October 2026

</td>
<td>December 2026</td>
</tr>
<tr>
<td>
May 25, 2026 *
</td>
<td>
May 25, 2026 *
</td>
<td>
Not Applicable
</td>
<td>November 2026</td>
<td> January 2027

</td>
<td>April 2027</td>
</tr>
<tr>
<td>
September 25, 2026 *
</td>
<td>
September 25, 2026 *
</td>
<td>
Not Applicable
</td>
<td>March 2027</td>
<td> May 2027

</td>
<td>July 2027</td>
</tr>
<tr>
<td>
January 25, 2027 *
</td>
<td>
January 25, 2027 *
</td>
<td>
Not Applicable
</td>
<td>July 2027</td>
<td> October 2027

</td>
<td>December 2027</td>
</tr>
<tr>
<td>
May 25, 2027 *
</td>
<td>
May 25, 2027 *
</td>
<td>
Not Applicable
</td>
<td>November 2027</td>
<td> January 2028

</td>
<td>April 2028</td>
</tr>
<tr>
<td>
September 25, 2027 *
</td>
<td>
September 25, 2027 *
</td>
<td>
Not Applicable
</td>
<td>March 2028</td>
<td> May 2028

</td>
<td>July 2028</td>
</tr>
<tr>
<td>
January 25, 2028 *
</td>
<td>
January 25, 2028 *
</td>
<td>
Not Applicable
</td>
<td>July 2028</td>
<td> October 2028

</td>
<td>December 2028</td>
</tr>
<tr>
<td>
May 25, 2028 *
</td>
<td>
May 25, 2028 *
</td>
<td>
Not Applicable
</td>
<td>November 2028</td>
<td> January 2029

</td>
<td>April 2029</td>
</tr>
<tr>
<td>
September 25, 2028 *
</td>
<td>
September 25, 2028 *
</td>
<td>
Not Applicable
</td>
<td>March 2029</td>
<td> May 2029

</td>
<td>July 2029</td>
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<a id='_bookmark259609' tabindex='-1' aria-hidden='true'></a><p>All applications are due by 5:00 PM local time of applicant organization. </p>

<p>Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.</p>
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September 26, 2028
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<p class="Normal">Not Applicable</p>
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<a id='_bookmark259617' tabindex='-1' aria-hidden='true'></a>Required Application Instructions
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<p>It is critical that applicants follow the Multi-Project (M) Instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, except where instructed to do otherwise (in this NOFO or in a Notice from the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11164">NIH Guide for Grants and Contracts</a>). Conformance to all requirements (both in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> and the NOFO) is required and strictly enforced. Applicants must read and follow all application instructions in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a>, follow the program-specific instructions. <b>Applications that do not comply with these instructions may be delayed or not accepted for review.</b></p>
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<a id='_bookmark262226' tabindex='-1' aria-hidden='true'></a><p style="margin-left:0in;">There are several options available to submit your application through Grants.gov to NIH and Department of Health and Human Services partners. You <strong>must</strong> use one of these submission options to access the application forms for this opportunity.</p><ol><li>Use the <a href="https://public.era.nih.gov/assist/landing.era?tabId=0819b5fc-46b7-4f02-b6b7-127e5a4e19fa">NIH ASSIST system</a> to prepare, submit and track your application online.</li><li>Use an institutional system-to-system (S2S) solution to prepare and submit your application to Grants.gov and <a href="https://public.era.nih.gov/commons/">eRA Commons</a> to track your application. Check with your institutional officials regarding availability.</li></ol>
</div>

<div id="tocDiv">
<div class="heading1" tabindex="0">Table of Contents</div>
<div class="toc-link"><a href="#_Part1.OverviewInformation">Part 1. Overview Information</a></div><div class="toc-link P_SingleIndent"><a href="#_KeyDates">Key Dates</a></div><div class="toc-link"><a href="#_Part2.FullTextofAnnouncement">Part 2. Full Text of Announcement</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionI.NoticeofFundingOpportunityDescription">Section I. Notice of Funding Opportunity Description</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionII.AwardInformation">Section II. Award Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIII.EligibilityInformation">Section III. Eligibility Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionIV.ApplicationandSubmissionInformation">Section IV. Application and Submission Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionV.ApplicationReviewInformation">Section V. Application Review Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVI.AwardAdministrationInformation">Section VI. Award Administration Information</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVII.AgencyContacts">Section VII. Agency Contacts</a></div><div class="toc-link P_SingleIndent"><a href="#_SectionVIII.OtherInformation">Section VIII. Other Information</a></div>
</div><br/>

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<a id='_bookmark259619' tabindex='-1' aria-hidden='true'></a><a name="_Part 2. Full Text of Announcement"></a><h1>Part 2. Full Text of Announcement</h1>
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<a id='_bookmark259620' tabindex='-1' aria-hidden='true'></a><a name="_Section I. Notice of Funding Opportunity Description"></a><h2>Section I. Notice of Funding Opportunity Description</h2>
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<a id='_bookmark259621' tabindex='-1' aria-hidden='true'></a><h4>Purpose</h4><p>This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. NCI-Designated Cancer Centers serve as major sources of discovery into the nature of cancer and of the development of more effective approaches to prevention, diagnosis, and therapy. They contribute significantly to the development of Shared Resources that support cancer relevant research, and they collaborate and coordinate their research efforts with other NCI-funded programs and investigators.</p><p>The objectives of the NCI Cancer Centers Program are to foster highly interactive cancer research through support of the following:</p><ul><li>Formal, interactive scientific Research Programs comprised of investigators with common scientific interests and goals, yielding competitively funded research grants and contracts and productive collaborations;</li><li>Centralized Shared Resources that provide access to technologies, services, and scientific consultation that enhance scientific interaction and productivity;</li><li>Strategic planning and evaluation that further the research agenda of the Center;</li><li>Developmental Funding that allows the Center to pursue newly identified priorities, strengthen weaker scientific areas, and explore new collaborations;</li><li>Activities that engage the populations within the catchment area in the conducted research and other Center activities;</li><li>Efforts to coordinate and enhance existing cancer research education, training, and career development activities;</li><li>Centralized Cancer Center Administration for resources and services, fiscal management and other supportive activities; and</li><li>Centralized scientific oversight of cancer clinical trials.</li></ul><p>NCI support to Cancer Centers is intended to foster excellence in research across a broad spectrum of scientific and medical concerns relevant to cancer. To facilitate discovery and its translation into direct benefit to patients and the general public, the NCI awards CCSGs to institutions that have a critical mass of cancer-relevant scientific research. The CCSG focus on research derives from the belief that a culture of discovery, scientific excellence, transdisciplinary research, and collaboration yields tangible benefits extending far beyond the generation of new knowledge.</p><h4>Background</h4><p>The National Cancer Act officially established the Cancer Centers Program in 1971. The legislation was based on the report of a congressional committee, which concluded that a formalized Cancer Centers Program would provide a unity of purpose, a centralized platform for sharing concepts and resources, and a management structure necessary to achieve progress toward the goal of preventing and curing cancer. The Act grandfathered in twelve existing Centers that were already receiving support through a variety of NCI grants and contracts and authorized the establishment of additional Centers. It also implemented a standard funding mechanism (the P30 Cancer Center Support Grant or CCSG) and guidelines, and created an administrative and organizational home for the Program at the NCI.</p><p>Based on this early legislation, qualified applicant institutions receive the CCSG award and accompanying NCI designation for successfully meeting a spectrum of rigorous competitive standards associated with scientific and organizational merit. While CCSG requirements have evolved over the years, the grant continues to support research infrastructure that enhances collaborative, transdisciplinary research productivity. CCSG grants provide funding for formalized cancer Research Programs, Shared Resources, scientific and administrative management, planning and evaluation activities, development of new scientific opportunities, community outreach and engagement, coordination of cancer training and education, and centralized clinical trial oversight and functions.</p><p>Although the CCSG does not directly fund the wider range of activities at Cancer Centers, an NCI-Designated Cancer Center links state-of-the-art research and care, thus perpetuating the translational continuum. To decrease cancer incidence and mortality among populations within its catchment area, including underserved populations, it also establishes partnerships with other health delivery systems and state and community agencies for dissemination of evidence-based findings.</p><p>Over the past several decades, the number of NCI-Designated Cancer Centers has grown extensively; today they are in a variety of organizational settings across the United States. An NCI-Designated Cancer Center is a local, regional, and national resource, directly serving its community and, through the knowledge it creates, the nation as a whole.</p><p>The NCI recognizes three types of Cancer Centers:</p><ul><li><strong>Basic Cancer Centers</strong> have scientific agendas primarily focused on basic laboratory research. While not all basic findings require a translational endpoint, basic cancer centers conduct pre-clinical translation and develop linkages with other institutions that will foster application of laboratory findings for public benefit where appropriate.</li><li><strong>Clinical Cancer Centers</strong> have scientific agendas focused on basic laboratory; clinical; and prevention, cancer control, and population-based science. All areas of science are linked collaboratively.</li><li><strong>Comprehensive Cancer Centers </strong>demonstrate reasonable depth and breadth of cancer research activities in each of three major areas: basic laboratory; clinical; and prevention, control, population-based science, as demonstrated in the formal Research Programs. Comprehensive Cancer Centers also have substantial transdisciplinary research that bridges these scientific areas, which is evaluated in the Research Programs and as part of the Six Essential Characteristics (i.e. Transdisciplinary Collaboration and Coordination; see below). They are effective in serving their catchment area, as well as the broader population, through the cancer research they support and the cancer control activities they undertake, as demonstrated in Community Outreach and Engagement. They integrate cancer training and education of biomedical researchers and community health care professionals into programmatic efforts to enhance the scientific mission and potential of the Center, as demonstrated by the Cancer Research Training and Education Coordination component. Comprehensive Centers are expected to be strong in all four areas indicated above; strengths in some areas cannot mitigate weaknesses in one or more other areas.</li></ul><p><i><strong>NOTE: </strong></i>Clinical and Comprehensive Cancer Centers serve a specific <i><strong>catchment area</strong></i>, and in addition to cancer research of broad applicability, they conduct research of particular relevance to their catchment area. A Centers catchment area is the self-defined geographic area that the Center serves or intends to serve in the research it conducts, the communities it engages, and the outreach it performs. It must include the area from which the Center draws the majority of its patients, but may extend beyond that, and it must include the local area surrounding the Cancer Center. It must be population-based, e.g., using census tracts, zip codes, county or state lines, or other geographically-defined boundaries.</p><h4>The Six Essential Characteristics of an NCI-Designated Cancer Center</h4><p>A successful NCI-Designated Cancer Center demonstrates strength in six essential characteristics. Together, these characteristics maximize its scientific potential and produce a whole that is greater than the sum of its parts:</p><ul><li><strong>Physical Space:</strong> Physical facilities dedicated to the conduct of cancer focused research, and to the Centers Shared Resources, and administration, are appropriate and adequate for the task.</li><li><strong>Organizational Capabilities:</strong> The Center takes maximum advantage of institutional capabilities in cancer research, engaging in appropriate planning and evaluation of Center strategies and activities. If a consortium is proposed, the consortium institution(s) add significant cancer research expertise to the Center.</li><li><strong>Transdisciplinary Collaboration and Coordination:</strong> Substantial coordination, interaction, and collaboration, both among Center members from a variety of disciplines and between Center members and investigators in other institutions, enhance and add value to the productivity and quality of research. As appropriate to the nature of the research, Centers facilitate transition of scientific findings through the translational continuum, via coordination of research across NCI and other funding mechanisms and through collaborations with other partners.</li><li><strong>Cancer Focus:</strong> The structure and objectives of the Center's Research Programs and other components, as well as, the Center members' grants, contracts, publications,<strong> </strong>demonstrate a clearly defined cancer research focus.</li><li><strong>Institutional Commitment:</strong> The Center is a formal organizational component of the institution, with sufficient space, positions, and discretionary resources to ensure its stability and fulfill the Centers objectives. The Center Director has authorities appropriate for managing the Center and furthering its scientific mission. The institution recognizes team science in its promotion and tenure policies.</li><li><strong>Center Director:</strong> The Director is a highly qualified scientist and administrator with leadership experience and expertise appropriate for establishing a vision for the Center, advancing scientific goals, and managing a complex organization. She or he is effective in using institutionally designated authorities to manage the Center.</li></ul><h4>Major Research Areas of Cancer Centers and Types of Interactions</h4><p>An NCI-Designated Cancer Center should feature vigorous interactions across its research areas, facilitating collaboration between basic laboratory; clinical; and prevention, control and population-based science investigators and the formal Research Programs of which they are a part. The organizational approach should serve the science of the institution, with reasonable breadth and depth of cancer-focused scientific faculty and dedicated research facilities.</p><p>In addition, Centers should ensure that they are both fostering basic discovery and, as applicable, facilitating transition of scientific findings through the translational pipeline (i.e., basic to pre-clinical and early clinical development, then to Phase III trials or other types of definitive studies appropriate to the nature of the research). Discoveries may be advanced through NCI and other peer-reviewed translational science and clinical trial funding mechanisms (e.g. grants for SPOREs, program projects, consortia for Phase 0/I/II Cancer Prevention Clinical Trials Program, and the NCI National Clinical Trials Network or NCTN) and other collaborative strategies, including external partnerships. All Centers are encouraged to establish collaborative links that maximize productivity and result in appropriate application of findings. The form and extent of these activities may vary, based on the type of Center.</p><p>Depending on Center type, the major research areas may include the following:</p><ul><li><strong>Basic Laboratory Research:</strong> Centers use their base of support to promote breadth and depth in basic laboratory research and transdisciplinary collaborations among investigators in basic discovery and other research areas, both within the Center and with other external partners.</li><li><strong>Clinical Research: </strong>Cancer Centers engage in a broad spectrum of clinical studies with a variety of forms of sponsorship. A Cancer Center is a major source of innovative investigator-initiated clinical studies that can be exported to NCI's NCTN or other appropriate externally peer-reviewed funded mechanisms. Clinical studies involve relevant laboratory research whenever possible. Cancer Centers foster translation between the laboratory and clinic and conduct early proof-of-principle clinical trials and lead, and/or participate in, NCIs NCTN. Cancer Centers also participate in trials initiated by industry and other NCI-designated Cancer Centers and other external partners.</li><li><strong>Prevention, Control, and Population Science Research:</strong> While Cancer Centers may not be able to conduct research in all aspects of prevention, cancer control, and population science, and no one area is required, they demonstrate depth in grant support across several thematic areas (e.g., epidemiology, primary prevention, early detection, health services, dissemination, palliation, and survivorship). They also demonstrate appropriate collaborative links to other research areas within the Center and with other NCI-Designated Cancer Centers and other external partners.</li></ul><h4>Consortium Centers</h4><p>NCI supports the affiliation of independent scientific institutions with distinct scientific expertise with NCI-Designated cancer centers to contribute to the development and actualization of the cancer center's research agenda. This formalized relationship strengthens the science of the Center and further extends the benefits of its cancer research. Once approved by NCI following peer-review, a consortium partner becomes a formal part of the Cancer Center and may describe themselves as a part of the X NCI-Designated Cancer Center. They may not display the NCI Cancer Center identity badges independently nor describe themselves as NCI-Designated.</p><p>Only renewal (Type 2) applications may propose consortium arrangements, which must be fully functioning at the time of application; Type 1 applications may not propose consortium arrangements.</p><p><strong>A consortium partner with clinical activities must:</strong></p><ul><li>Hold at least $2.5 million in direct cost NIH-funded research project grants that are classified as cancer research by NIHs Research, Condition, and Disease Categorization (RCDC), held by a minimum of 10 PD/PIs. These grants cannot be counted as part of the Center until the consortium arrangement is approved by NCI, following acceptance of the arrangement by the Study Section  as part of their overall review of the P30 CCSG application.</li><li>Contribute continuing tangible commitments to the Center. These may include direct financial support of cancer research; discretionary funds placed at the Center Directors disposal; protected cancer research time to support programmatic goals; leadership positions in the Centers Research Programs or other components; efforts that expand the Centers catchment area and activities of the Centers Community Outreach and Engagement; common strategic planning and priorities (recruitment, clinical trials, grants, etc.); physical space for cancer research, etc.</li><li>Be fully integrated at the level of membership and institutional engagement into the Cancer Center at the time of the CCSG application, as evidenced by a history of collaboration, including joint grants and publications, and mechanisms for including geographically dispersed members in programmatic activities. Common fundraising across the partner institutions is encouraged, but not required.</li><li>Subject all clinical protocols to the Cancer Centers Protocol Review and Monitoring System (PRMS), Data and Safety Monitoring Institutional Plan (DSMP), and Clinical Protocol and Data Management (CPDM). A joint Institutional Review Board (IRB) for evaluation of all cancer research across the partner institutions is encouraged, but not required.</li><li>Have participation of the partners members in centers disease- or modality-focused groups, PRMS, and DSMP.</li><li>Grant the Cancer Center Director some influence in the management of the clinical cancer care program at the consortium partner to ensure that care is aligned with the research mission of the Center.</li><li>Have appropriate accrual to clinical trials proportionate to the patient population and clinical research capabilities of the consortium partner.</li><li>Have an appropriate cancer research administrative structure and staff to support cancer research, member engagement, and participation in Center activities, and that coordinates its efforts with the Center's administration.</li><li>Have a formal, written agreement (Memorandum of Understanding) in place to ensure the stability and integration of the consortium partnership. The agreement should include:<ul><li>A process for resolution of differences at the highest levels of institutional leadership</li><li>An integrated planning and evaluation process that enables achievement of the Centers research goals (e.g., identification of future recruitment needs, Shared Resources, Community Outreach and Engagement, and other activities)</li><li>Ongoing, tangible institutional commitments to the Cancer Center from all consortium partners. Such commitments should be appropriate to the nature of the consortium and may be demonstrated in a number of ways, including financial and in-kind contributions based on agreed upon formulas, housing and funding of Cancer Center cores, accrual to center-wide trials, active representation and engagement of members in Cancer Center Programs and committees, etc.</li><li>Full eligibility for membership in formal Research Programs and leadership positions in the Center</li><li>Reasonable access for all members to Shared Resources and clinical research materials including output from clinical trials, tissues, and HIPAA-compliant patient data</li><li>Center Director oversight of CCSG-supported Shared Resources, including those located in partner institutions</li><li>A clear delineation of the Center Directors influence in the clinical operations at the consortium partner</li></ul></li></ul><p>A consortium partner without clinical activity must:</p><ul><li>Satisfy the requirements listed above, not including clinic-related activities, and hold at least $1.0 million in direct cost NIH-funded research project grants that are classified as cancer research by NIHs Research, Condition, and Disease Categorization (RCDC), held by a minimum of 5 PD/PIs. These grants cannot be counted as part of the Center until the research partnership arrangement is approved by NCI, following acceptance of the arrangement by the NCIs Cancer Centers Study Section (A) as part of their overall review of the P30 CCSG application.</li></ul><p><i><strong>DURATION:</strong></i><strong> </strong>The initial budget period will be five years. In order to enable more long-range planning and pursue high-risk research, Centers may be eligible for an additional two years, for a maximum award period of seven years. Eligibility for the additional years will be based on merit at peer review, sustained exceptional progress, stability, and longevity of the Cancer Center, and contingent upon an administrative review by NCI staff and approval of the National Cancer Advisory Board.</p>
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<a id='_bookmark259623' tabindex='-1' aria-hidden='true'></a><p>Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs.</p>
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<a id='_bookmark259624' tabindex='-1' aria-hidden='true'></a><p>See <a href="#">Section VIII. Other Information</a> for award authorities and regulations.</p>
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<a id='_bookmark259625' tabindex='-1' aria-hidden='true'></a><a name="_Section II. Award Information"></a><h2>Section II. Award Information</h2>
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<a id='_bookmark259626' tabindex='-1' aria-hidden='true'></a>Funding Instrument
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<p>Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.</p>
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New
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Renewal
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Resubmission
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Revision
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<a id='_bookmark259629' tabindex='-1' aria-hidden='true'></a><p>The <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11116"><font color="#0000ff">OER Glossary</font></a> and the <a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82400">How to Apply - Application Guide</a> provides details on these application types. Only those application types listed here are allowed for this NOFO.</p>
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<p>Optional: Accepting applications that either propose or do not propose clinical trial(s).</p>
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<a id='_bookmark259631' tabindex='-1' aria-hidden='true'></a><a href="https://grants.nih.gov/grants/guide/url_redirect.htm?id=82370">Need help determining whether you are doing a clinical trial?</a>
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<p>The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.</p>
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<p style="margin-left:0px;"><strong>New (Type 1) applications:</strong> Budget should not exceed $1.2 million (Basic Cancer Center), $1.4 million (Clinical Cancer Center), $1.5 million (Comprehensive Cancer Center) in direct costs per year for the project period.</p><p style="margin-left:0px;"><strong>Renewal (Type 2) applications:</strong> Application budgets are not limited but need to reflect the actual needs of the proposed project.</p>
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<p>5 years</p>
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<a id='_bookmark259635' tabindex='-1' aria-hidden='true'></a><p>NIH grants policies as described in the <a href="http://grants.nih.gov/grants/guide/url_redirect.htm?id=11120">NIH Grants Policy Statement</a> will apply to the applications submitted and awards made from this NOFO.</p>
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PAR-25-444-Revised-Full-Announcement.html

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<title>PAR-25-444: Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)</title>

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<div id="page-title" class="heading1" tabindex="0">Department of Health and Human Services</div>

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<a id='_bookmark259587' tabindex='-1' aria-hidden='true'></a><a name="_Part 1. Overview Information"></a><h1>Part 1. Overview Information</h1>
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<p>National Institutes of Health (<a href="http://www.nih.gov">NIH</a>)</p>
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<a id='_bookmark259590' tabindex='-1' aria-hidden='true'></a>Components of Participating Organizations
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<p>National Cancer Institute (<a href="https://www.cancer.gov/" target="_blank" rel="noreferrer">NCI</a>)
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<a id='_bookmark259592' tabindex='-1' aria-hidden='true'></a>Funding Opportunity Title
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<span class="title">Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)</span>
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<p><a href="http://grants.nih.gov/grants/funding/ac_search_results.htm?text_curr=p30&Search.x=0&Search.y=0&Search_Type=Activity">P30</a> Center Core Grants</p>
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Reissue of

<a href="https://www.grants.gov/search-results-detail/336070" target="_blank" rel="noreferrer">PAR-21-321</a>

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